Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils
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DOI: 10.1073/pnas.1918481117
Abstract: Significance Two unresolved problems in Alzheimer’s disease (AD) are its onset and propagation, linked to Aβ peptide aggregation. Fibrils of Aβ42 may grow by monomer addition at their ends. Additionally, through so-called secondary nucleation, fibrils… read more here.
Keywords: secondary nucleation; self replication; alzheimer associated; sides fibrils ... See more keywords