Activation of astrocytic sigma‐1 receptor exerts antidepressant‐like effect via facilitating CD38‐driven mitochondria transfer
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23850
Abstract: Despite sigma‐1 receptor (Sig‐1R) is a promising therapeutic target in depression, little is known regarding the cellular mechanisms underlying its antidepressant responses. Here, we demonstrated that astrocyte can be a direct cellular target of Sig‐1R… read more here.
Keywords: like effect; activation; sigma receptor; sig ... See more keywords
From late Sunday evening meetings to the formation of a special interest group for racially minoritised populations ()
Sign Up to like & getrecommendations! Published in 2022 at "Sexually Transmitted Infections"
DOI: 10.1136/sextrans-2021-055373
Abstract: A new special interest group (SIG) within the British Association for Sexual Health and HIV (BASHH) has been formed to focus on the sexual health needs of racially minoritised populations. As two professionals involved in… read more here.
Keywords: health; group; sexual health; racially minoritised ... See more keywords
Prognostic implication of heterogeneity and trajectory progression induced by enzalutamide in prostate cancer
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DOI: 10.3389/fendo.2023.1148898
Abstract: Background Enzalutamide, as a second-generation endocrine therapy drug for prostate cancer (PCa), is prominent representative among the synthetic androgen receptor antagonists. Currently, there is lack of enzalutamide-induced signature (ENZ-sig) for predicting progression and relapse-free survival… read more here.
Keywords: progression; pca; enz sig; sig ... See more keywords
Gut microbiota from sigma-1 receptor knockout mice induces depression-like behaviors and modulates the cAMP/CREB/BDNF signaling pathway
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DOI: 10.3389/fmicb.2023.1143648
Abstract: Introduction Depression is a common mental disorder that affects approximately 350 million people worldwide. Much remains unknown about the molecular mechanisms underlying this complex disorder. Sigma-1 receptor (Sig-1R) is expressed at high levels in the… read more here.
Keywords: like behaviors; gut microbiota; depression; sig ... See more keywords
Sigma-1 receptor-regulated efferocytosis by infiltrating circulating macrophages/microglial cells protects against neuronal impairments and promotes functional recovery in cerebral ischemic stroke
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DOI: 10.7150/thno.77088
Abstract: Background: Efferocytosis of apoptotic neurons by macrophages is essential for the resolution of inflammation and for neuronal protection from secondary damage. It is known that alteration of the Sigma-1 receptor (Sig-1R) is involved in the… read more here.
Keywords: efferocytosis; sigma receptor; sig knockout; sig ... See more keywords