SIGIRR mutation identified in human necrotizing enterocolitis (NEC) disrupts STAT3-dependent microRNA expression in neonatal gut.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular gastroenterology and hepatology"
DOI: 10.1016/j.jcmgh.2021.09.009
Abstract: BACKGROUND AND AIMS Single Immunoglobulin Interleukin-1 Related Receptor (SIGIRR) is a major inhibitor of Toll-like Receptor (TLR) signaling. Our laboratory identified a novel SIGIRR stop mutation (p.Y168X) in an infant who succumbed to severe NEC.… read more here.
Keywords: expression; neonatal gut; sigirr; stat3 dependent ... See more keywords
A Promising Genetic Target for a Deadly Disease: Single Immunoglobulin Interleukin 1 (SIGIRR) Mutations in Necrotizing Enterocolitis
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2021.10.011
Abstract: ecrotizing enterocolitis (NEC) is a deadly disease Nthat primarily affects premature infants, but the precise etiology is not well understood. Premature infants are predisposed to NEC because of their immature intestinal epithelium and host defenses,… read more here.
Keywords: deadly disease; hepatology; promising genetic; gastroenterology ... See more keywords
A Splice Switch in SIGIRR Causes a Defect of IL-37-Dependent Anti-Inflammatory Activity in Cystic Fibrosis Airway Epithelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147748
Abstract: Cystic fibrosis (CF) is a hereditary disease typically characterized by infection-associated chronic lung inflammation. The persistent activation of toll-like receptor (TLR) signals is considered one of the mechanisms for the CF hyperinflammatory phenotype; however, how… read more here.
Keywords: airway epithelial; sigirr; anti inflammatory; inflammatory activity ... See more keywords
Single immunoglobulin and Toll-interleukin-1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll-like receptor-4 signaling pathway: A clinical and experimental study
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2020.11379
Abstract: Single immunoglobulin and Toll-interleukin-1 receptor domain-containing molecule (SIGIRR) is a specific inhibitor of IL-1R and Toll-like receptor (TLR) signaling and considered a potential target for the treatment of inflammatory diseases. Pathogenic mechanisms associated with the… read more here.
Keywords: pancreatitis; signaling pathway; toll; vitro ... See more keywords