Siglec‐15 promotes the migration of liver cancer cells by repressing lysosomal degradation of CD44
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Letters"
DOI: 10.1002/1873-3468.14169
Abstract: Sialic acid‐binding immunoglobulin‐like lectin‐15 (Siglec‐15) has been identified as a novel potential target for cancer immunotherapy. Here, we explored the role of Siglec‐15 in human hepatoma cells. In this study, we found that the expression… read more here.
Keywords: siglec; hepatoma cells; promotes migration; cd44 ... See more keywords
Polysialic acid and Siglec-E orchestrate negative feedback regulation of microglia activation
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03601-z
Abstract: Polysialic acid (polySia) emerges as a novel regulator of microglia activity. We recently identified polysialylated proteins in the Golgi compartment of murine microglia that are released in response to inflammatory stimulation. Since exogenously added polySia… read more here.
Keywords: siglec; polysialic acid; response; polysia ... See more keywords
Unveiling Molecular Recognition of Sialoglycans by Human Siglec-10
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101231
Abstract: Summary Siglec-10 is an inhibitory I-type lectin selectively recognizing sialoglycans exposed on cell surfaces, involved in several patho-physiological processes. The key role Siglec-10 plays in the regulation of immune cell functions has made it a… read more here.
Keywords: siglec; human siglec; sialoglycans human; recognition sialoglycans ... See more keywords
Common determinants of severe Covid-19 infection are explicable by SARS-CoV-2 secreted glycoprotein interaction with the CD33-related Siglecs, Siglec-3 and Siglec-5/14
Sign Up to like & getrecommendations! Published in 2020 at "Medical Hypotheses"
DOI: 10.1016/j.mehy.2020.110168
Abstract: Abstract SARS-CoV-2 interaction with the ACE-2 receptor cannot alone explain the demography and remarkable variation in clinical progression of Covid-19 infection. Unlike SARS-CoV, the cause of SARS, several SARS-CoV-2 spike glycans contain sialic acid residues.… read more here.
Keywords: siglec; cd33; severe covid; sars cov ... See more keywords
GATA3 Encapsulated by Tumor-Associated Macrophage-Derived Extracellular Vesicles Promotes Immune Escape and Chemotherapy Resistance of Ovarian Cancer Cells by Upregulating the CD24/Siglec-10 Axis.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00557
Abstract: Tumor-associated macrophages (TAMs) possess great potential in the development of ovarian cancer (OC). Aberrant GATA-binding protein-3 (GATA3) expression has been found in TAM-derived extracellular vesicles (EVs). This study is intended to investigate the regulatory mechanism… read more here.
Keywords: cd24 siglec; gata3; immune escape; resistance ... See more keywords
Dissecting the Ability of Siglecs To Antagonize Fcγ Receptors
Sign Up to like & getrecommendations! Published in 2024 at "ACS Central Science"
DOI: 10.1021/acscentsci.3c00969
Abstract: Fcγ receptors (FcγRs) play key roles in the effector function of IgG, but their inappropriate activation plays a role in several disease etiologies. Therefore, it is critical to better understand how FcγRs are regulated. Numerous… read more here.
Keywords: siglec siglec; siglecs antagonize; siglec; ability ... See more keywords
A sulfonamide sialoside analog for targeting Siglec-8 and -F on im-mune cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b05769
Abstract: The Siglec family of sialic acid binding im-munoglobulin-like cell surface receptors have emerged as attractive targets for cell directed therapies due to their restricted expression on immune cells, endocytic properties and ability to modulate receptor… read more here.
Keywords: siglec; sialoside analog; sulfonamide sialoside; targeting siglec ... See more keywords
Siglec-6 is a Target for Chimeric Antigen Receptor T-cell Treatment of Chronic Lymphocytic Leukemia
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01188-3
Abstract: The only current curative treatment for chronic lymphocytic leukemia (CLL) is allogenic hematopoietic stem cell transplantation. Chimeric antigen receptor treatment targeting CD19 for CLL achieved some complete responses, suggesting the need for alternative or combinational… read more here.
Keywords: siglec; cll; treatment; antigen ... See more keywords
γδ+ T-cell-derived IL-17A stimulates airway epithelial/stromal cells to secrete G-CSF, promoting lung-specific pathogenic Siglec-F+ neutrophil development in PPE-induced emphysema
Sign Up to like & getrecommendations! Published in 2025 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-025-01301-x
Abstract: Neutrophils play a pivotal role in the progression of IL-17-mediated airway inflammation, but the mechanisms underlying their pathological differentiation remain poorly understood. In this study, we identified a distinct population of lung-specific pathogenic Siglec-F+ neutrophils… read more here.
Keywords: lung; siglec; emphysema; csf ... See more keywords
Siglec-6 as a therapeutic target for cell migration and adhesion in chronic lymphocytic leukemia
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-48678-3
Abstract: Siglec-6 is a lectin receptor with restricted expression in the placenta, mast cells and memory B-cells. Although Siglec-6 is expressed in patients with chronic lymphocytic leukemia (CLL), its pathophysiological role has not been elucidated. We… read more here.
Keywords: migration; chronic lymphocytic; siglec; cll ... See more keywords
Increased expression of Siglec-9 in chronic obstructive pulmonary disease
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09120-5
Abstract: Chronic obstructive pulmonary disease (COPD) is a common inflammatory lung disease. Sialic acid-binding immunoglobulin-type lectins 9 (Siglec-9) is predominantly expressed on innate immune cells and has been shown to exert regulatory effect on immune cells… read more here.
Keywords: siglec; chronic obstructive; obstructive pulmonary; disease ... See more keywords