Siglec-7 expression is reduced on a natural killer (NK) cell subset of obese humans
Sign Up to like & getrecommendations! Published in 2017 at "Immunologic Research"
DOI: 10.1007/s12026-017-8942-y
Abstract: Obesity leads to an altered adipocytokine production negatively effecting the function of natural killer cells (NK cells), which are important effector cells of the innate immune system. NK cells provide a defence against tumour cells… read more here.
Keywords: natural killer; siglec expression; cell; expression ... See more keywords
Siglec-15 expression in diffuse gliomas and its correlation with MRI morphologic features and apparent diffusion coefficient
Sign Up to like & getrecommendations! Published in 2024 at "Acta Radiologica"
DOI: 10.1177/02841851241286109
Abstract: Background Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) enhances tumor immune escape and leads to tumor growth. Purpose To investigate the expression of Siglec-15 in diffuse gliomas and its correlation with tumor magnetic resonance imaging (MRI)… read more here.
Keywords: siglec expression; mri; tumor; expression ... See more keywords
Extracellular CIRP decreases Siglec-G expression on B-1a cells skewing them towards a pro-inflammatory phenotype in sepsis
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Medicine"
DOI: 10.1186/s10020-021-00318-y
Abstract: Background Sepsis is a life-threatening disease syndrome caused by a dysregulated host response to infection and injury. Extracellular cold-inducible RNA-binding protein (eCIRP) acts as a damage-associated molecular pattern. Peritoneal cavity (PerC) B-1a cells attenuate inflammation and… read more here.
Keywords: siglec expression; sepsis; perc cells; mice ... See more keywords
Decreased Siglec-9 Expression on Natural Killer Cell Subset Associated With Persistent HBV Replication
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01124
Abstract: Siglec-9 is an MHC-independent inhibitory receptor selectively expressed on CD56dim NK cells. Its role in infection diseases has not been investigated yet. Here, we studied the potential regulatory roles of NK Siglec-9 in the pathogenesis… read more here.
Keywords: decreased siglec; hbv; expression; siglec expression ... See more keywords
Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1159085
Abstract: Background Sialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) was reported to be a novel immune checkpoint molecule comparable to programmed cell death 1 ligand 1 (PD-L1). However, its expression profile and immunosuppressive mechanisms in the glioma tumor… read more here.
Keywords: dynamic change; siglec expression; glioma; tumor ... See more keywords
Expression and function of Siglec-15 in RLPS and its correlation with PD-L1: Bioinformatics Analysis and Clinicopathological Evidence
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Medical Sciences"
DOI: 10.7150/ijms.77193
Abstract: Purpose: Retroperitoneal liposarcoma (RLPS) is a rare malignancy without effective treatment. Since current treatment for unresectable RLPS is unsatisfactory, immunotherapy and targeted therapy are urgently needed. Siglec-15 is a transmembrane protein highly homologous to PD-L1… read more here.
Keywords: siglec rlps; function siglec; expression; siglec expression ... See more keywords