Sigma-1 Receptor Antagonists: A New Class of Neuromodulatory Analgesics.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-50174-1_9
Abstract: The sigma-1 receptor is a unique ligand-operated chaperone present in key areas for pain control, in both the peripheral and central nervous system. Sigma-1 receptors interact with a variety of protein targets to modify their… read more here.
Keywords: sigma; sigma receptors; sigma antagonists; sigma receptor ... See more keywords
Targeting immune‐driven opioid analgesia by sigma‐1 receptors: Opening the door to novel perspectives for the analgesic use of sigma‐1 antagonists
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2018.02.008
Abstract: Graphical abstract Figure. No caption available. ABSTRACT Immune cells have a known role in pronociception, since they release a myriad of inflammatory algogens which interact with neurons to facilitate pain signaling. However, these cells also… read more here.
Keywords: targeting immune; sigma; sigma antagonists; opioid analgesia ... See more keywords