Activation of astrocytic sigma‐1 receptor exerts antidepressant‐like effect via facilitating CD38‐driven mitochondria transfer
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23850
Abstract: Despite sigma‐1 receptor (Sig‐1R) is a promising therapeutic target in depression, little is known regarding the cellular mechanisms underlying its antidepressant responses. Here, we demonstrated that astrocyte can be a direct cellular target of Sig‐1R… read more here.
Keywords: like effect; activation; sigma receptor; sig ... See more keywords
Sigma-1 Receptor Antagonists: A New Class of Neuromodulatory Analgesics.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-50174-1_9
Abstract: The sigma-1 receptor is a unique ligand-operated chaperone present in key areas for pain control, in both the peripheral and central nervous system. Sigma-1 receptors interact with a variety of protein targets to modify their… read more here.
Keywords: sigma; sigma receptors; sigma antagonists; sigma receptor ... See more keywords
Sigma-1 receptor ligand PD144418 and sigma-2 receptor ligand YUN-252 attenuate the stimulant effects of methamphetamine in mice
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05268-2
Abstract: RationalePrevious research indicates that the selective sigma-1 receptor ligand PD144418 and the selective sigma-2 ligands YUN-252 can inhibit cocaine-induced hyperactivity. The effects of these ligands on other stimulants, such as methamphetamine, have not been reported.ObjectivesThe… read more here.
Keywords: methamphetamine; receptor ligand; sigma; yun 252 ... See more keywords
Sigma-1 receptor ligands improves ventricular repolarization-related ion remodeling in rats with major depression disorder.
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05697-4
Abstract: RATIONALE It has been reported that patients with major depressive disorder (MDD) are prone to developing ventricular arrhythmias. Moreover, the Sigma-1 receptor not only plays a crucial role in MDD but has also been shown… read more here.
Keywords: depression; repolarization related; ica; sigma receptor ... See more keywords
New consensus multivariate models based on PLS and ANN studies of sigma-1 receptor antagonists
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-017-3444-3
Abstract: AbstractThe treatment of neuropathic pain is very complex and there are few drugs approved for this purpose. Among the studied compounds in the literature, sigma-1 receptor antagonists have shown to be promising. In order to… read more here.
Keywords: multivariate models; consensus; mlp ann; sigma receptor ... See more keywords
Inhibition of Noncanonical Ca2+ Oscillation/Calcineurin/GSK-3β Pathway Contributes to Anti-Inflammatory Effect of Sigma-1 Receptor Activation.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03439-2
Abstract: Further understanding the mechanism for microglia activation is necessary for developing novel anti-inflammatory strategies. Our previous study found that the activation of sigma-1 receptor can effectively inhibit the neuroinflammation, independent of the canonical mechanisms, such… read more here.
Keywords: anti inflammatory; calcineurin; activation; sigma receptor ... See more keywords
Activation of Sigma-1 Receptor Enhanced Pericyte Survival via the Interplay Between Apoptosis and Autophagy: Implications for Blood–Brain Barrier Integrity in Stroke
Sign Up to like & getrecommendations! Published in 2019 at "Translational Stroke Research"
DOI: 10.1007/s12975-019-00711-0
Abstract: Stroke is a cerebrovascular disorder that affects many people worldwide. Pericytes play an important role in stroke progression and recovery. The sigma-1 receptor (σ-1R) signaling pathway has been suggested as having promising neuroprotective potential in… read more here.
Keywords: apoptosis; apoptosis autophagy; pericyte survival; sigma receptor ... See more keywords
Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the σ1 receptor
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.11.010
Abstract: HIGHLIGHTSActivation of the sigma‐1 receptor, an ER chaperone, is neuroprotective in Alzheimer's disease.Invalidation of the sigma‐1 receptor facilitated A&bgr;25–35 peptide learning deficit and toxicity in mice.APPSweInd/S1RKO mice presented, at 8 months of age, a more… read more here.
Keywords: appsweind s1rko; toxicity; mice; sigma receptor ... See more keywords
Chronic inhibition of the sigma-1 receptor exacerbates atrial fibrillation susceptibility in rats by promoting atrial remodeling.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116837
Abstract: AIMS This study aimed to evaluate the effects of the sigma-1 receptor (S1R) on atrial fibrillation (AF) susceptibility in rats. MAIN METHODS Rats were randomly assigned into three groups for intraperitoneal treatment with saline (CTL… read more here.
Keywords: atrial fibrillation; group; fibrillation susceptibility; susceptibility rats ... See more keywords
Sigma 1 receptor activation modifies intracellular calcium exchange in the G93AhSOD1 ALS model
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.07.012
Abstract: Aberrations in intracellular calcium (Ca2+) have been well established within amyotrophic lateral sclerosis (ALS), a severe motor neuron disease. Intracellular Ca2+ concentration is controlled in part through the endoplasmic reticulum (ER) mitochondria Ca2+ cycle (ERMCC).… read more here.
Keywords: intracellular calcium; ca2; sigma receptor; activation ... See more keywords
Sigma‐2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma‐2 receptor ligands to PGRMC1
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2016.12.023
Abstract: Graphical abstract Figure. No Caption available. Abstract A controversial relationship between sigma‐2 and progesterone receptor membrane component 1 (PGRMC1) proteins, both representing promising targets for the therapy and diagnosis of tumors, exists since 2011, when… read more here.
Keywords: pgrmc1; progesterone receptor; receptor membrane; sigma ... See more keywords