Sigma-1 Receptor Antagonists: A New Class of Neuromodulatory Analgesics.
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DOI: 10.1007/978-3-319-50174-1_9
Abstract: The sigma-1 receptor is a unique ligand-operated chaperone present in key areas for pain control, in both the peripheral and central nervous system. Sigma-1 receptors interact with a variety of protein targets to modify their… read more here.
Keywords: sigma; sigma receptors; sigma antagonists; sigma receptor ... See more keywords
PO-213 Sigma receptors: development of novel therapeutic approaches in pancreatic cancer
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DOI: 10.1136/esmoopen-2018-eacr25.731
Abstract: Introduction Pancreatic cancer is a highly malignant tumour, poorly responsive to conventional therapies that result in a progressive resistance to treatment. Sigma receptors (sigma-1 and sigma-2) are widespread in central nervous system and multiple peripheral… read more here.
Keywords: sigma; pancreatic cancer; sigma receptors; sigma receptor ... See more keywords