SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1586248
Abstract: ABSTRACT Autophagosome-lysosome fusion is a common critical step in various forms of macroautophagy/autophagy including mitophagy, the selective degradation of mitochondria. Regulations of this fusion process remain poorly defined. Here we have determined the role of… read more here.
Keywords: sigmar1; sigmar1 sigma; clearance; fusion ... See more keywords
Abstract 1034: SIGMAR1 as a novel potential prognostic biomarker that regulates PD-L1 expression in oral cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-1034
Abstract: Background: The SIGMAR1 receptor is a regulator of immunity and inflammation. Together, these key processes can support or restrain cancer progression and response to therapy. Nevertheless, the effect of SIGMAR1 on the modulation of oral… read more here.
Keywords: sigmar1; cancer; sigmar1 novel; expression ... See more keywords
SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-025-06393-7
Abstract: Bladder cancer (BC) is one of the most common malignancies worldwide. G protein-coupled receptors (GPCRs) are a large family of transmembrane proteins that are increasingly recognised as key players in cancer biology, affecting cell signalling… read more here.
Keywords: sigmar1; cancer; stress; cell ... See more keywords
Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1118770
Abstract: Sigma1 receptor protein (Sigmar1) is a small, multifunctional molecular chaperone protein ubiquitously expressed in almost all body tissues. This protein has previously shown its cardioprotective roles in rodent models of cardiac hypertrophy, heart failure, and… read more here.
Keywords: inflammation; sigmar1; pulmonary fibrosis; surfactant proteins ... See more keywords
Deletion of Sigmar1 leads to increased arterial stiffness and altered mitochondrial respiration resulting in vascular dysfunction
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2024.1386296
Abstract: Sigmar1 is a ubiquitously expressed, multifunctional protein known for its cardioprotective roles in cardiovascular diseases. While accumulating evidence indicate a critical role of Sigmar1 in cardiac biology, its physiological function in the vasculature remains unknown.… read more here.
Keywords: sigmar1; arterial stiffness; deletion sigmar1; sigmar1 mice ... See more keywords
The regulatory role of Sigmar1 in CVB3-induced myocarditis.
Sign Up to like & getrecommendations! Published in 2025 at "General physiology and biophysics"
DOI: 10.4149/gpb_2025011
Abstract: Sigma-1 receptor (Sigmar1) is associated with endoplasmic reticulum (ER) stress. This study investigated whether Sigmar1 affect myocarditis progression via Coxsackievirus B3 (CVB3)-caused ER stress. Neonatal mouse cardiomyocytes (NMCs) were transfected with Sigmar1 and/or stress-induced phosphoprotein… read more here.
Keywords: sigmar1; cvb3 induced; stub1 overexpression; cvb3 ... See more keywords