SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1586248
Abstract: ABSTRACT Autophagosome-lysosome fusion is a common critical step in various forms of macroautophagy/autophagy including mitophagy, the selective degradation of mitochondria. Regulations of this fusion process remain poorly defined. Here we have determined the role of… read more here.
Keywords: sigmar1; sigmar1 sigma; clearance; fusion ... See more keywords
Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1118770
Abstract: Sigma1 receptor protein (Sigmar1) is a small, multifunctional molecular chaperone protein ubiquitously expressed in almost all body tissues. This protein has previously shown its cardioprotective roles in rodent models of cardiac hypertrophy, heart failure, and… read more here.
Keywords: inflammation; sigmar1; pulmonary fibrosis; surfactant proteins ... See more keywords