YAP charge patterning mediates signal integration through transcriptional co-condensates
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-62157-3
Abstract: Transcription factor dynamics are used to selectively engage gene regulatory programs. Biomolecular condensates have emerged as an attractive signaling module in this process, but the underlying mechanisms are not well-understood. Here, we probe the molecular… read more here.
Keywords: signal integration; yap; integration transcriptional; transcriptional condensates ... See more keywords
Achieving neuronal dynamics with spike encoding and spatial-temporal summation in vanadium-based threshold switching memristor for asynchronous signal integration.
Sign Up to like & getrecommendations! Published in 2024 at "Nanoscale horizons"
DOI: 10.1039/d4nh00484a
Abstract: Artificial neuronal devices that emulate the dynamics of biological neurons are pivotal for advancing brain emulation and developing bio-inspired electronic systems. This paper presents the design and demonstration of an artificial neuron circuit based on… read more here.
Keywords: signal integration; asynchronous signal; threshold switching; summation ... See more keywords
Molecular-scale spatio-chemical control of the activating-inhibitory signal integration in NK cells
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abc1640
Abstract: Molecular devices for the spatial control of activating and inhibitory receptors help in their signal integration. The role of juxtaposition of activating and inhibitory receptors in signal inhibition of cytotoxic lymphocytes remains strongly debated. The… read more here.
Keywords: molecular scale; activating inhibitory; signal integration; control activating ... See more keywords
115 Engineered T cells directed at tumors with defined allelic loss
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0115
Abstract: Background Cell therapy, with all its promise as a powerful solid-tumor modality, is still hampered by the fundamental obstacle of cancer therapy: the acute shortage of truly tumor-specific targets. It is well known that an… read more here.
Keywords: tumor; signal integration; 115 engineered; cancer ... See more keywords
Temporal Differences between Load and Movement Signal Integration in the Sensorimotor Network of an Insect Leg.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neurophysiology"
DOI: 10.1152/jn.00399.2021
Abstract: Nervous systems face a torrent of sensory inputs, including proprioceptive feedback. Signal integration depends on spatially and temporally coinciding signals. It is unclear how relative time delays affect multimodal signal integration from spatially distant sense… read more here.
Keywords: signal integration; temporal differences; movement; network ... See more keywords