Signal peptidase I processed secretory signal sequences: Selection for and against specific amino acids at the second position of mature protein.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.044
Abstract: Signal peptides direct proteins from the cytoplasm to the periplasm. These N-terminal peptides are cleaved upon entry to the periplasm by either signal peptidase I, or signal peptidase II for lipoproteins. Signal peptidase I is… read more here.
Keywords: amino acids; position; signal peptidase; peptidase ... See more keywords
Stringency of bacterial prolipoprotein signal peptidase (LspA) in recognition of signal peptides - Structure-function correlation.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.05.069
Abstract: Bacterial lipid modification of proteins is an essential post-translational event committed by Phosphatidylglycerol: prolipoprotein diacylglyceryl transferase (Lgt) by catalysing diacyglyceryl transfer from Phosphatidylglycerol to cysteine present in the characteristic 'lipobox' ([LVI] (-3) [ASTVI] (-2) [GAS]… read more here.
Keywords: prolipoprotein signal; signal peptidase; signal peptides; peptidase lspa ... See more keywords
AfSec1 is a signal peptidase and removes signal peptides of 1,3-β-glucanosyltransferases in Aspergillus fumigatus.
Sign Up to like & getrecommendations! Published in 2023 at "Medical mycology"
DOI: 10.1093/mmy/myad005
Abstract: To identify the infection mechanism of Aspergillus fumigatus, which is an opportunistic fungal pathogen, we analyzed the expression profile of the whole genome of A. fumigatus during infection of murine macrophages. A previously reported RNA-seq… read more here.
Keywords: promoter; strain; signal peptidase; afsec1 strain ... See more keywords
The human signal peptidase complex acts as a quality control enzyme for membrane proteins
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abo5672
Abstract: Cells need to detect and degrade faulty membrane proteins to maintain homeostasis. In this study, we identify a previously unknown function of the human signal peptidase complex (SPC)—the enzyme that removes endoplasmic reticulum (ER) signal… read more here.
Keywords: signal peptidase; membrane proteins; peptidase complex; quality control ... See more keywords
Signal Peptidase-Mediated Cleavage of the Anti-σ Factor RsiP at Site 1 Controls σP Activation and β-Lactam Resistance in Bacillus thuringiensis
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03707-21
Abstract: β-Lactam antibiotics are important for the treatment of many bacterial infections. However, resistance mechanisms have become increasingly more prevalent. ABSTRACT In Bacillus thuringiensis, β-lactam antibiotic resistance is controlled by the extracytoplasmic function (ECF) σ factor… read more here.
Keywords: signal peptidase; cleavage; resistance; rsip ... See more keywords
Escherichia coli signal peptidase recognizes and cleaves archaeal signal sequence
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297917070070
Abstract: Tk1884, an open reading frame encoding α-amylase in Thermococcus kodakarensis, was cloned with the native signal sequence and expressed in Escherichia coli. Heterologous gene expression resulted in secretion of the recombinant protein to the extracellular… read more here.
Keywords: signal sequence; escherichia coli; signal peptidase; sequence ... See more keywords
Spc1 regulates the signal peptidase-mediated processing of membrane proteins
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cell Science"
DOI: 10.1242/jcs.258936
Abstract: ABSTRACT Signal peptidase (SPase) cleaves the signal sequences (SSs) of secretory precursors. It contains an evolutionarily conserved membrane protein subunit, Spc1, that is dispensable for the catalytic activity of SPase and whose role remains unknown.… read more here.
Keywords: spase; membrane proteins; spc1; signal peptidase ... See more keywords
Non-Specific Signal Peptidase Processing of Extracellular Proteins in Staphylococcus aureus N315
Sign Up to like & getrecommendations! Published in 2023 at "Proteomes"
DOI: 10.3390/proteomes11010008
Abstract: Staphylococcus aureus is one of the major community-acquired human pathogens, with growing multidrug-resistance, leading to a major threat of more prevalent infections to humans. A variety of virulence factors and toxic proteins are secreted during… read more here.
Keywords: signal peptidase; processing; peptidase; spase ... See more keywords
Signal peptidase 21 suppresses cell proliferation, migration, and invasion via the PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "PeerJ"
DOI: 10.7717/peerj.14206
Abstract: Background In a previous study, a total of 568 differentially expressed proteins including the signal peptidase SPC21 were identified from lung adenocarcinoma (LUAD) and paired normal lung tissues. In this study, the role of SPC21… read more here.
Keywords: signal peptidase; lung adenocarcinoma; luad; migration invasion ... See more keywords