Targeting the cluster of differentiation 47/signal-regulatory protein alpha axis in myeloid malignancies.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in hematology"
DOI: 10.1097/moh.0000000000000691
Abstract: PURPOSE OF REVIEW The antitumor activity of macrophages is regulated by a balance of prophagocytic and antiphagocytic signals. Cluster of differentiation 47 (CD47), the dominant macrophage immune checkpoint ('do not eat me' signal), interacts with… read more here.
Keywords: regulatory protein; myeloid malignancies; myeloid; protein alpha ... See more keywords
Signal and regulatory effects of methylglyoxal in eukaryotic cells (review)
Sign Up to like & getrecommendations! Published in 2017 at "Applied Biochemistry and Microbiology"
DOI: 10.1134/s0003683817030103
Abstract: Methylglyoxal (MG) is one of the physiological glucose metabolites formed in living organisms. The data on the influence of MG on different internal systems of eukaryotic cells, including the central signaling pathways, are been discussed… read more here.
Keywords: regulatory effects; signal regulatory; effects methylglyoxal; methylglyoxal eukaryotic ... See more keywords
Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009662
Abstract: Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that SIRPA decreased in vitro infection by a number of pathogenic viruses, including… read more here.
Keywords: anti viral; signal regulatory; regulatory protein; sirpa ... See more keywords
Signal and regulatory mechanisms involved in spore development of Phytophthora and Peronophythora
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.984672
Abstract: Oomycetes cause hundreds of destructive plant diseases, threatening agricultural production and food security. These fungus-like eukaryotes show multiple sporulation pattern including the production of sporangium, zoospore, chlamydospore and oospore, which are critical for their survival,… read more here.
Keywords: mechanisms involved; regulatory mechanisms; spore development; phytophthora peronophythora ... See more keywords