A unique signal sequence of the chemokine receptor CCR7 promotes package into COPII vesicles for efficient receptor trafficking
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2vma1217-492r
Abstract: Chemokine receptors are considered to belong to the group of G protein‐coupled receptors that use the first transmembrane domain as signal anchor sequence for membrane insertion instead of a cleavable N‐terminal signal sequence. Chemokine recognition… read more here.
Keywords: signal sequence; ccr7; sequence chemokine; receptor ... See more keywords
Pathogenic Signal Sequence Mutations in Progranulin Disrupt SRP Interactions Required for mRNA Stability
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.05.003
Abstract: SUMMARY Cells have evolved quality control pathways to prevent the accumulation of improperly localized proteins, which are often toxic. One of these pathways, regulation of aberrant protein production (RAPP), recognizes aberrant secretory proteins during translation… read more here.
Keywords: progranulin disrupt; signal sequence; grn; sequence mutations ... See more keywords
Identification of a Novel Rhizopus‐specific Antigen by Screening with a Signal Sequence Trap and Evaluation as a Possible Diagnostic Marker of Mucormycosis
Sign Up to like & getrecommendations! Published in 2017 at "Medical Mycology"
DOI: 10.1093/mmy/myw146
Abstract: Abstract Mucormycosis is the second most common mould infection, often indistinguishable from other invasive mould infections such as aspergillosis. Although an appropriate antifungal therapy is effective at an early stage of the infection, there is… read more here.
Keywords: rhizopus specific; signal sequence; mucormycosis; sequence trap ... See more keywords
Mechanism of Signal Sequence Handover From NAC To SRP on Ribosomes During ER-protein Targeting
Sign Up to like & getrecommendations! Published in 2022 at "Microscopy and Microanalysis"
DOI: 10.1126/science.abl6459
Abstract: The nascent polypeptide–associated complex (NAC) interacts with newly synthesized proteins at the ribosomal tunnel exit and competes with the signal recognition particle (SRP) to prevent mistargeting of cytosolic and mitochondrial polypeptides to the endoplasmic reticulum… read more here.
Keywords: srp; nac; srp ribosomes; nascent polypeptide ... See more keywords
Escherichia coli signal peptidase recognizes and cleaves archaeal signal sequence
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297917070070
Abstract: Tk1884, an open reading frame encoding α-amylase in Thermococcus kodakarensis, was cloned with the native signal sequence and expressed in Escherichia coli. Heterologous gene expression resulted in secretion of the recombinant protein to the extracellular… read more here.
Keywords: signal sequence; escherichia coli; signal peptidase; sequence ... See more keywords
Signal Sequence-Dependent Orientation of Signal Peptide Fragments to Exosomes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23063137
Abstract: Signal peptides (SPs) not only mediate targeting to the endoplasmic reticulum (ER) but also play important roles as biomarkers and substances with physiological activity in extracellular fluids including blood. SPs are thought to be degraded… read more here.
Keywords: extracellular fluid; sequence; sequence dependent; protein ... See more keywords