Histone deacetylase 5‐induced deficiency of signal transducer and activator of transcription‐3 acetylation contributes to spinal astrocytes degeneration in painful diabetic neuropathy
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24328
Abstract: Diabetes patients with painful diabetic neuropathy (PDN) show severe spinal atrophy, suggesting pathological changes of the spinal cord contributes to central sensitization. However, the cellular changes and underlying molecular mechanisms within the diabetic spinal cord… read more here.
Keywords: diabetic neuropathy; spinal astrocytes; signal transducer; painful diabetic ... See more keywords
Signal transducer and activator of transcription family is a prognostic marker associated with immune infiltration in endometrial cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24315
Abstract: Signal transducer and activator of transcription (STAT) is a unique protein family that binds to DNA and plays a vital role in regulating major physiological cellular processes. Seven STAT genes have been identified in the… read more here.
Keywords: family; signal transducer; infiltration endometrial; activator transcription ... See more keywords
Loss of Tyrosine Phosphatase Delta Promotes Gastric Cancer Progression via Signal Transducer and Activator of Transcription 3 Pathways
Sign Up to like & getrecommendations! Published in 2019 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-019-05637-z
Abstract: BackgroundThe protein tyrosine phosphatase delta (PTPRD) is a tumor suppressor, and its role in gastric cancer (GC) remains poorly understood.MethodsThe expressions of PTPRD were determined based on public data. In addition, the mRNA expressions of… read more here.
Keywords: signal transducer; gastric cancer; transducer activator; tyrosine phosphatase ... See more keywords
Prohibitin 1 interacts with signal transducer and activator of transcription 3 in T-helper 17 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Immunology letters"
DOI: 10.1016/j.imlet.2019.12.008
Abstract: T-helper 17 (Th17) cells are involved in the occurrence and development of several inflammation-associated diseases. Interleukin (IL)-17, the main cytokine secreted by differentiated Th17 cells, mediates immunoreactions and plays important roles in immunological diseases, including… read more here.
Keywords: signal transducer; activator transcription; transducer activator; th17 cells ... See more keywords
MicroRNA‐93 alleviates neuropathic pain through targeting signal transducer and activator of transcription 3
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.01.027
Abstract: Abstract Emerging evidence suggests that microRNAs (miRNAs) play a critical role in the pathogenesis of neuropathic pain. However, the exact role of miRNAs in regulating neuropathic pain remains largely unknown. In this study, we aimed… read more here.
Keywords: overexpression mir; signal transducer; neuropathic pain; cci rats ... See more keywords
Tyrosine Kinase 2 and Janus Kinase‒Signal Transducer and Activator of Transcription Signaling and Inhibition in Plaque Psoriasis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Academy of Dermatology"
DOI: 10.1016/j.jaad.2021.06.869
Abstract: Plaque psoriasis is a common, chronic, systemic, immune-mediated inflammatory disease. The Janus kinase‒signal transducer and activator of transcription (JAK-STAT) pathway plays a major role in intracellular cytokine signaling in inflammatory processes involved in psoriasis. Although… read more here.
Keywords: jak; plaque psoriasis; signal transducer; kinase signal ... See more keywords
Signal transducer and activator of transcription 3 as a potential therapeutic target for Graves’ orbitopathy
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2021.111363
Abstract: The roles of signal transducer and activator of transcription 3 (STAT3) in inflammation, oxidative stress, and adipogenesis during Graves' orbitopathy (GO) are incompletely understood. Here, STAT3 expression in orbital tissues (from individuals with GO and… read more here.
Keywords: activator transcription; transducer activator; signal transducer; graves orbitopathy ... See more keywords
BP-1-102 and silencing of Fascin-1 by RNA interference inhibits the proliferation of mouse pituitary adenoma AtT20 cells via the signal transducer and activator of transcription 3/fascin-1 pathway
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2020.1758088
Abstract: Abstract Introduction The expression levels of signal transducer and activator of transcription 3 (STAT3) protein and Fascin-1 were inhibited using the STAT3 inhibitor BP-1-102 and RNA interference, respectively, to investigate the expression of AtT20 in… read more here.
Keywords: signal transducer; transducer activator; group; proliferation ... See more keywords
Impact of heat stress on prolactin-mediated ovarian JAK-STAT signaling in postpubertal gilts
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Animal Science"
DOI: 10.1093/jas/skac118
Abstract: Abstract Heat stress (HS) compromises almost every aspect of animal agriculture including reproduction. In pigs, this infecundity is referred to as seasonal infertility (SI), a phenotype including ovarian dysfunction. In multiple species, HS-induced hyperprolactinemia has… read more here.
Keywords: signal transducer; transducer activator; activator transcription;
Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient.
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Infectious Disease Journal"
DOI: 10.1097/inf.0000000000002090
Abstract: A signal transducer and activator of transcription-1-deficient patient presented with prolonged fever, cachexia, anemia, hypoalbuminemia and finally relapsing debilitating mycobacterial osteomyelitis while receiving a previously effective antimycobacterial treatment. Progression despite rigorous workup and multiple antibiotics… read more here.
Keywords: transcription deficient; activator transcription; signal transducer; deficient patient ... See more keywords
Dermokine contributes to epithelial–mesenchymal transition through increased activation of signal transducer and activator of transcription 3 in pancreatic cancer
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DOI: 10.1111/cas.13347
Abstract: Dermokine (DMKN) was first identified in relation to skin lesion healing and skin carcinoma. Recently, its expression was associated with pancreatic cancer tumorigenesis, although its involvement remains poorly understood. Herein, we showed that DMKN loss… read more here.
Keywords: signal transducer; activator transcription; transducer activator; pancreatic cancer ... See more keywords