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Published in 2018 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2018.04.002
Abstract: Until the late 1990s, class A G protein-coupled receptors (GPCRs) were believed to function as monomers. Indirect evidence that they might internalize or even signal as dimers has emerged, along with proof that class C…
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Keywords:
gpcrs signal;
interaction stoichiometry;
class;
signal transducers ... See more keywords
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Published in 2021 at "Current opinion in rheumatology"
DOI: 10.1097/bor.0000000000000810
Abstract: PURPOSE OF REVIEW The Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling proteins represent a group of intracellular kinase molecules that play a central role in the signaling pathways induced by cytokines, chemokines, and…
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Keywords:
signal transducers;
activators transcription;
janus kinase;
kinase signal ... See more keywords
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Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15070835
Abstract: The superimposition of the X-ray complexes of cyclohexanediones (i.e., TUB015), described by our research group, and nocodazole, within the colchicine binding site of tubulin provided an almost perfect overlap of both ligands. This structural information…
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Keywords:
activators transcription;
transducers activators;
signal transducers;
transcription stat3 ... See more keywords