Regulation of signal transduction by gangliosides in lipid rafts: focus on GM3–IR and GM1–TrkA interactions
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14532
Abstract: The interactions between gangliosides and proteins belonging to the same or different lipid domains and their influence on physiological and pathological states have been analysed in detail. A well‐known factor impacting on lipid–protein interactions and… read more here.
Keywords: gm1 trka; signal transduction; gm1; regulation signal ... See more keywords
Identification of a New Cholesterol‐Binding Site within the IFN‐γ Receptor that is Required for Signal Transduction
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105170
Abstract: The cytokine interferon‐gamma (IFN‐γ) is a master regulator of innate and adaptive immunity involved in a broad array of human diseases that range from atherosclerosis to cancer. IFN‐γ exerts it signaling action by binding to… read more here.
Keywords: chol; signal transduction; cholesterol; receptor ... See more keywords
Induction of Signal Transduction by Using Non‐Channelrhodopsin‐Type Optogenetic Tools
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DOI: 10.1002/cbic.201700635
Abstract: Signal transductions are the basis for all cellular functions. Previous studies investigating signal transductions mainly relied on pharmacological inhibition, RNA interference, and constitutive active/dominant negative protein expression systems. However, such studies do not allow the… read more here.
Keywords: non channelrhodopsin; channelrhodopsin type; signal transduction; type optogenetic ... See more keywords
Sestrin 3 Protects Against Diet‐Induced Nonalcoholic Steatohepatitis in Mice Through Suppression of Transforming Growth Factor β Signal Transduction
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30820
Abstract: Sestrin 3 (Sesn3) belongs to the three‐member sestrin protein family. Sestrins have been implicated in antioxidative stress, adenosine monophosphate–activated protein kinase and mammalian target of rapamycin signal transduction, and metabolic homeostasis. However, the role of… read more here.
Keywords: nonalcoholic steatohepatitis; sesn3; diet induced; mice ... See more keywords
Inhibitory Effects of Quercetin on Progression of Human Choriocarcinoma Cells Are Mediated Through PI3K/AKT and MAPK Signal Transduction Cascades
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25637
Abstract: As a major dietary flavonol, quercetin mitigates proliferation and progression of cancer due to its anti‐angiogenic, anti‐inflammatory, anti‐oxidant, and apoptotic biological effects on cells. Although its apoptotic effects have been reported for various cancers, little… read more here.
Keywords: jeg3 cells; choriocarcinoma; jar jeg3; mapk signal ... See more keywords
Cryptochromes: Photochemical and structural insight into magnetoreception
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4124
Abstract: Cryptochromes (CRYs) function as blue light photoreceptors in diverse physiological processes in nearly all kingdoms of life. Over the past several decades, they have emerged as the most likely candidates for light‐dependent magnetoreception in animals,… read more here.
Keywords: insight magnetoreception; structural insight; cryptochromes photochemical; signal transduction ... See more keywords
Effect of cadmium on Rho GTPases signal transduction during osteoclast differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23510
Abstract: Osteoclasts are the key target cells for cadmium (Cd)‐induced bone metabolism diseases, while Rho GTPases play an important role in osteoclast differentiation and bone resorption. To identify new therapeutic targets of Cd‐induced bone diseases; we… read more here.
Keywords: osteoclast differentiation; cadmium; signal transduction; rho gtpases ... See more keywords
Interactions of a Signal Transduction Protein Investigated by Fluorescence Stopped-Flow Kinetics.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1197-5_3
Abstract: To understand cellular processes such as biochemical pathways and signaling networks, we need to understand binding and reaction rates of often competing reactions, their dependence on cellular concentrations of participating molecules, and the regulation of… read more here.
Keywords: protein investigated; fluorescence stopped; transduction protein; interactions signal ... See more keywords
In Vitro Analysis of Hypertensive Signal Transduction: Kinase Activation, Kinase Manipulation, and Physiologic Outputs.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6625-7_16
Abstract: Studying signal transduction in hypertension model systems in vitro will include several steps: (1) develop the cell culture model and induce hypertensive changes, (2) observe kinase activation, (3) manipulate signal transduction pathways, and (4) observe… read more here.
Keywords: physiologic outputs; signal transduction; kinase; kinase activation ... See more keywords
In Vivo Analysis of Hypertension: Induction of Hypertension, In Vivo Kinase Manipulation, and Assessment of Physiologic Outputs.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6625-7_32
Abstract: Using an in vivo model system to study signal transduction will include several steps: (1) induce hypertension in the animal, (2) manipulate kinase activation and signal transduction pathways as desired, and (3) observe physiologic outputs.… read more here.
Keywords: vivo; physiologic outputs; kinase; vivo analysis ... See more keywords
An Analysis of the Intracellular Signal Transduction of Peripheral Blood Leukocytes in Animal Models of Diabetes Using Flow Cytometry.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8994-2_17
Abstract: Various complications of diabetes are induced by the augmentation of chronic inflammation and attenuation of immunity. Leukocytes, which play major roles in inflammation and immune responses, are affected by the glycemic status and blood insulin… read more here.
Keywords: using flow; peripheral blood; blood; flow cytometry ... See more keywords