Aryl hydrocarbon receptor signaling activation in systemic sclerosis attenuates collagen production and is a potential antifibrotic target.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106886
Abstract: Systemic sclerosis (SSc) is a systemic autoimmune disease that often leads to fibrosis of multiple organs, and there are no effective treatments. Aryl hydrocarbon receptor (AhR) is a highly evolutionarily conserved transcription factor activated by… read more here.
Keywords: ahr signaling; hydrocarbon receptor; aryl hydrocarbon; systemic sclerosis ... See more keywords
Anti-inflammatory effect of Vaccinium oldhamii stems through inhibition of NF-κB and MAPK/ATF2 signaling activation in LPS-stimulated RAW264.7 cells
Sign Up to like & getrecommendations! Published in 2019 at "BMC Complementary and Alternative Medicine"
DOI: 10.1186/s12906-019-2720-4
Abstract: BackgroundVaccinium oldhamii (V. oldhamii) has been reported to exert a variety of the pharmacological properties such as anti-oxidant activity, anti-cancer activity, and inhibitory activity of α-amylase and acetylcholinesterase. However, the anti-inflammatory activity of V. oldhamii… read more here.
Keywords: anti inflammatory; vos; oldhamii; signaling activation ... See more keywords
Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer’s Disease-like Neuropathology in a Mouse Model for Down Syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12010111
Abstract: Down syndrome (DS) is the most frequent genetic cause of intellectual disability and is strongly associated with Alzheimer’s disease (AD). Brain insulin resistance greatly contributes to AD development in the general population and previous studies… read more here.
Keywords: kyccsrk peptide; signaling activation; brain; insulin signaling ... See more keywords
The p38 MAPK Signaling Activation in Colorectal Cancer upon Therapeutic Treatments
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DOI: 10.3390/ijms21082773
Abstract: Pharmacological treatment of colorectal carcinoma currently proceeds through the administration of a combination of different chemotherapeutic agents. In the case of rectal carcinoma, radiation therapy also represents a therapeutic strategy. In an attempt at translating… read more here.
Keywords: p38 mapk; colorectal carcinoma; therapeutic treatments; mapk signaling ... See more keywords
Atypical p38 Signaling, Activation, and Implications for Disease
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DOI: 10.3390/ijms22084183
Abstract: The mitogen-activated protein kinase (MAPK) p38 is an essential family of kinases, regulating responses to environmental stress and inflammation. There is an ever-increasing plethora of physiological and pathophysiological conditions attributed to p38 activity, ranging from… read more here.
Keywords: activation implications; implications disease; p38; signaling activation ... See more keywords