Hippo Signaling: Autophagy Waits in the Wings.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.02.014
Abstract: Crosstalk between signaling networks can help coordinate diverse cellular functions. In this issue of Developmental Cell, Tyra et al. identify connections between the cell-growth-promoting transcription factor YAP/Yorkie and the autophagy-regulating kinase Ulk1/Atg1. read more here.
Keywords: hippo signaling; signaling autophagy; waits wings; autophagy waits ... See more keywords
A division of labor in mTORC1 signaling and autophagy
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aav3530
Abstract: Autophagy and mTORC1 signaling are mediated by distinct p62 protein species (Sanchez-Garrido et al., in 4 December 2018 issue). In human cells, the p62 protein acts as an adaptor in various signaling pathways as well… read more here.
Keywords: mtorc1 signaling; mtorc1; labor mtorc1; division labor ... See more keywords
Defects of Nutrient Signaling and Autophagy in Neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.836196
Abstract: Neurons are post-mitotic cells that allocate huge amounts of energy to the synthesis of new organelles and molecules, neurotransmission and to the maintenance of redox homeostasis. In neurons, autophagy is not only crucial to ensure… read more here.
Keywords: defects nutrient; nutrient signaling; energy; signaling autophagy ... See more keywords
Gq Signaling in Autophagy Control: Between Chemical and Mechanical Cues
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DOI: 10.3390/antiox11081599
Abstract: All processes in human physiology relies on homeostatic mechanisms which require the activation of specific control circuits to adapt the changes imposed by external stimuli. One of the critical modulators of homeostatic balance is autophagy,… read more here.
Keywords: control chemical; control; autophagy control; signaling autophagy ... See more keywords
Loss of Neuropilin-2 in Murine Mesenchymal-like Colon Cancer Organoids Causes Mesenchymal-to-Epithelial Transition and an Acquired Dependency on Insulin-Receptor Signaling and Autophagy
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DOI: 10.3390/cancers14030671
Abstract: Simple Summary Many cancer types are reported to have high lymphangiogenic receptor Neuropilin-2 (Nrp2) expression, including colorectal cancer (CRC). Nrp2 is shown to be associated with tumor progression in vivo and poor prognosis in CRC… read more here.
Keywords: crc; signaling autophagy; mesenchymal epithelial; receptor ... See more keywords