The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.08.149
Abstract: Diabetic nephropathy (DN) with high morbidity and mortality is one of the most severe diabetes complications and affects nearly one-third of people with diabetes. Our present experiment was designed to assess the potential therapeutic of… read more here.
Keywords: sirt1; signaling axis; pgc signaling; pgc ... See more keywords
B02 The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2019.12.071
Abstract: Author(s): Momcilovic, M; Lee, JT; Braas, D; Graeber, TG; Parlati, F; Demo, S; Li, R; Gricowski, M; Shuman, R; Ibarra, J; Fridman, D; St.John, M; Bernthal, N; Federman, N; Yanagawa, J; Dubinett, SM; Sadeghi, S;… read more here.
Keywords: b02 gsk3; adaptive glutamine; gsk3 signaling; signaling axis ... See more keywords
The p38/MKP-1 signaling axis in oral cancer: Impact of tumor-associated macrophages.
Sign Up to like & getrecommendations! Published in 2020 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2020.104591
Abstract: Oral squamous cell carcinomas (OSCC) constitute over 95% of all head and neck malignancies. As a key component of the tumor microenvironment (TME), chronic inflammation contributes towards the development, progression, and regional metastasis of OSCC.… read more here.
Keywords: p38 mkp; signaling axis; tumor associated; mkp signaling ... See more keywords
Targeted Intervention of NF2-YAP Signaling Axis in CD24-Overexpressing Cells Contributes to Encouraging Therapeutic Effects in TNBC.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c10921
Abstract: Triple-negative breast cancer (TNBC) cells have not been usefully classified, and no targeted therapeutic plans are currently available, resulting in a high recurrence rate and metastasis potential. In this research, CD24high cells accounted for the… read more here.
Keywords: nf2 yap; cd24high cells; yap signaling; signaling axis ... See more keywords
Glioblastoma stem cells exploit the αvβ8 integrin-TGFβ1 signaling axis to drive tumor initiation and progression
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.248
Abstract: Glioblastoma (GBM) is a primary brain cancer that contains populations of stem-like cancer cells (GSCs) that home to specialized perivascular niches. GSC interactions with their niche influence self-renewal, differentiation and drug resistance, although the pathways… read more here.
Keywords: signaling axis; tgf; progression; integrin tgf ... See more keywords
Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts ovarian cancer malignancy
Sign Up to like & getrecommendations! Published in 2017 at "Oncogenesis"
DOI: 10.1038/oncsis.2016.86
Abstract: Integrins, a family of heterodimeric receptors for extracellular matrix, are promising therapeutic targets for ovarian cancer, particularly high-grade serous-type (HGSOC), as they drive tumor cell attachment, migration, proliferation and survival by activating focal adhesion kinase… read more here.
Keywords: signaling axis; integrin fak; fak; ovarian cancer ... See more keywords
A CD133-AKT-Wnt signaling axis drives glioblastoma brain tumor-initiating cells
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-1086-x
Abstract: Mechanistic insight into signaling pathways downstream of surface receptors has been revolutionized with integrated cancer genomics. This has fostered current treatment modalities, namely immunotherapy, to capitalize on targeting key oncogenic signaling nodes downstream of a… read more here.
Keywords: wnt signaling; wnt; signaling axis; cd133 akt ... See more keywords
Hepatic stellate cells promote intrahepatic cholangiocarcinoma progression via NR4A2/osteopontin/Wnt signaling axis
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01705-9
Abstract: Intrahepatic cholangiocarcinoma (ICC) is a highly fatal malignancy characterized by a vast amount of intra-tumoral fibroblasts. These fibroblasts are potentially implicated in maintaining the high aggressiveness of ICC, whereas its pro-cancer mechanisms remain scarcely reported.… read more here.
Keywords: wnt signaling; signaling axis; intrahepatic cholangiocarcinoma; hepatic stellate ... See more keywords
Helicobacter pylori-induced RASAL2 through activation of NF-kB promotes gastric tumorigenesis via β-catenin signaling axis.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.01.046
Abstract: BACKGROUND & AIMS Helicobacter pylori (H. pylori) infection is the predominant risk factor for gastric cancer. RAS protein activator like 2 (RASAL2) is considered a double-edged sword in carcinogenesis. Herein, we investigated the role of… read more here.
Keywords: gastric tumorigenesis; catenin; helicobacter pylori; signaling axis ... See more keywords
The signaling axis of Rac1-TFEB regulates autophagy and tumorigenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000000816
Abstract: Macroautophagy (hereafter referred to as autophagy) plays essential roles in cellular and organismal homeostasis. Transcription factor EB (TFEB) is a master regulator of autophagy and lysosome biogenesis. It is not fully understood how the function… read more here.
Keywords: tumorigenesis; signaling axis; tfeb; rac1 tfeb ... See more keywords
Abstract A31: Deregulation of NOTCH 1/NR4A2 signaling axis in head and neck cancer pathogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.aacrahns19-a31
Abstract: Background: Notch1 and its intracellular cytoplasmic domain (NICD) are dysregulated in many solid tumors, including head and neck squamous cell carcinoma (HNSCC), and associated with disease initiation and progression. NICD-mediated upregulation of nuclear receptor related… read more here.
Keywords: signaling axis; pathogenesis; cancer; nr4a2 signaling ... See more keywords