Molecular Glues: A New Approach to Modulating GPCR Signaling Bias
Sign Up to like & getrecommendations! Published in 2025 at "Biochemistry"
DOI: 10.1021/acs.biochem.4c00734
Abstract: G-protein-coupled receptors (GPCRs) transmit an extracellular chemical/biological signal across the cell membrane, stimulating an array of intracellular signaling cascades. Canonically, these extracellular signaling molecules bind to the endogenous ligand pocket (orthosteric pocket), which stabilizes either… read more here.
Keywords: glues new; gpcr signaling; molecular glues; signaling bias ... See more keywords
Fusion with Promiscuous Gα16 Subunit Reveals Signaling Bias at Muscarinic Receptors
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221810089
Abstract: A complex evaluation of agonist bias at G-protein coupled receptors at the level of G-protein classes and isoforms including non-preferential ones is essential for advanced agonist screening and drug development. Molecular crosstalk in downstream signaling… read more here.
Keywords: muscarinic receptors; agonist bias; signaling bias; bias ... See more keywords