Combined targeting of HEDGEHOG signaling and BRD4 as a novel therapeutic option against melanoma
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DOI: 10.18632/oncotarget.28441
Abstract: The Hedgehog-GLI (HH/GLI) pathway is aberrantly activated in several types of cancer. Canonical HH/ GLI pathway is triggered by binding of HH ligands to the twelve-pass transmembrane receptor Patched 1 (PTCH1), which retrieves its inhibition… read more here.
Keywords: hedgehog signaling; hedgehog; targeting hedgehog; gli ... See more keywords