The ER-mitochondria Ca2+ signaling in cancer progression: Fueling the monster.
Sign Up to like & getrecommendations! Published in 2021 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2021.03.006
Abstract: Cancer is a leading cause of death worldwide. All major tumor suppressors and oncogenes are now recognized to have fundamental connections with metabolic pathways. A hallmark feature of cancer cells is a reprogramming of their… read more here.
Keywords: mitochondria ca2; cancer; signaling cancer; ca2 ... See more keywords
[Therapeutic targeting of Notch signaling in cancer].
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin du cancer"
DOI: 10.1016/j.bulcan.2017.07.007
Abstract: The Notch pathway plays an essential role during embryonal development and tissue in adults. Notch signaling occurs through transmembrane receptors which undergo several proteolytic cleavages that lead to the release of the Notch intracytoplasmic domain… read more here.
Keywords: signaling cancer; targeting notch; notch; notch signaling ... See more keywords
Wnt signaling in cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.304
Abstract: Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer,… read more here.
Keywords: cancer; signaling cancer; wnt signaling;
Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abo0264
Abstract: Diacylglycerol (DAG) is a lipid second messenger that is generated in response to extracellular stimuli and channels intracellular signals that affect mammalian cell proliferation, survival, and motility. DAG exerts a myriad of biological functions through… read more here.
Keywords: diacylglycerol signaling; overarching roles; signaling cancer; roles diacylglycerol ... See more keywords
Neural Signaling in Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of neuroscience"
DOI: 10.1146/annurev-neuro-111020-092702
Abstract: Nervous system activity regulates development, homeostasis, and plasticity of the brain as well as other organs in the body. These mechanisms are subverted in cancer to propel malignant growth. In turn, cancers modulate neural structure… read more here.
Keywords: cancer; review; brain; neural signaling ... See more keywords
Wnt signaling in cancer: not a binary ON:OFF switch.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-19-1362
Abstract: In the March 1st issue of Cancer Research, we identified the Wnt receptor Fzd7 as an attractive therapeutic target for the treatment of gastric cancer. In summary, we showed that pharmacological inhibition of Wnt receptors,… read more here.
Keywords: cancer binary; binary switch; cancer; signaling cancer ... See more keywords
Bone Morphogenetic Protein Signaling in Cancer; Some Topics in the Recent 10 Years
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.883523
Abstract: Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGF-β) family, are multifunctional cytokines. BMPs have a broad range of functions, and abnormalities in BMP signaling pathways are involved in cancer progression. BMPs activate… read more here.
Keywords: bone morphogenetic; signaling cancer; cancer topics; protein signaling ... See more keywords
Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.924817
Abstract: The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) and its negative regulator kelch-like ECH-associated protein 1 (KEAP1) regulate various genes involved in redox homeostasis, which protects cells from stress conditions such as reactive… read more here.
Keywords: cancer oxidative; keap1; nrf2 keap1; keap1 signaling ... See more keywords
Frequent 4EBP1 Amplification Induces Synthetic Dependence on FGFR Signaling in Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14102397
Abstract: Simple Summary Our work establishes that amplification of 4EBP1, as a part of Chr. 8p11, creates a synthetic dependency on FGFR1 signaling in cancer. 4EBP1 is phosphorylated by FGFR1 and PI3K signaling, and accordingly cancer… read more here.
Keywords: pi3k; fgfr1; amplification; chr 8p11 ... See more keywords
Cadherin Signaling in Cancer and Autoimmune Diseases
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222413358
Abstract: Cadherins mediate cell–cell adhesion through a dynamic process that is strongly dependent on the cellular context and signaling. Cadherin regulation reflects the interplay between fundamental cellular processes, including morphogenesis, proliferation, programmed cell death, surface organization… read more here.
Keywords: signaling cancer; cancer autoimmune; cell; autoimmune diseases ... See more keywords
Emerging Roles of Hedgehog Signaling in Cancer Immunity
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021321
Abstract: Hedgehog–GLI (HH) signaling plays an essential role in embryogenesis and tissue homeostasis. Aberrant activation of the pathway through mutations or other mechanisms is involved in the development and progression of numerous types of cancer, including… read more here.
Keywords: hedgehog signaling; cancer immunity; emerging roles; signaling cancer ... See more keywords