Wnt/β-catenin signaling in cancers and targeted therapies
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00701-5
Abstract: Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence, advancement of malignant progression, development of poor… read more here.
Keywords: wnt catenin; targeted therapies; catenin signaling; catenin ... See more keywords
Molecular Targeting of ERKs/RSK2 Signaling in Cancers.
Sign Up to like & getrecommendations! Published in 2017 at "Current pharmaceutical design"
DOI: 10.2174/1381612823666170714142338
Abstract: Accumulating studies have provided concrete evidence that p90 ribosomal S6 kinase 2 (RSK2) is a key signaling molecule involved in cell proliferation, transformation, and cancer development. RSK2 is known to be an etiological gene of… read more here.
Keywords: molecular targeting; rsk2; targeting erks; rsk2 signaling ... See more keywords
The cAMP-signaling cancers: Clinically-divergent disorders with a common central pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1024423
Abstract: The cAMP-signaling cancers, which are defined by functionally-significant somatic mutations in one or more elements of the cAMP signaling pathway, have an unexpectedly wide range of cell origins, clinical manifestations, and potential therapeutic options. Mutations… read more here.
Keywords: signaling pathway; camp; signaling cancers; camp signaling ... See more keywords