The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Acta Pharmaceutica Sinica B"
DOI: 10.1016/j.apsb.2021.05.011
Abstract: Abstract The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the… read more here.
Keywords: cardiovascular metabolic; metabolic diseases; signaling cardiovascular; sting signaling ... See more keywords
Pepducin-mediated GPCR signaling in the cardiovascular system.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001236
Abstract: ABSTRACT Pepducins are small-lipidated peptides designed from the intracellular loops (iLs) of G protein-coupled receptors (GPCRs) that act in an allosteric manner to modulate the activity of GPCRs. Over the last two decades, pepducins have… read more here.
Keywords: pepducin mediated; signaling cardiovascular; cardiovascular system; gpcr signaling ... See more keywords
Wnt signaling in cardiovascular disease: opportunities and challenges
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Lipidology"
DOI: 10.1097/mol.0000000000000445
Abstract: Purpose of review Cardiometabolic diseases increasingly afflict our aging, dysmetabolic population. Complex signals regulating low-density lipoprotein receptor-related protein (LRP) and frizzled protein family members – the plasma membrane receptors for the cadre of Wnt polypeptide… read more here.
Keywords: wnt signaling; signaling cardiovascular; disease; opportunities challenges ... See more keywords
New Insights Into the Role of mTOR Signaling in the Cardiovascular System.
Sign Up to like & getrecommendations! Published in 2018 at "Circulation research"
DOI: 10.1161/circresaha.117.311147
Abstract: The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal function, and cell metabolism. mTOR interacts with specific adaptor proteins to form… read more here.
Keywords: mtor signaling; signaling cardiovascular; mtor; role mtor ... See more keywords
Clinical Potential of Adrenomedullin Signaling in the Cardiovascular System.
Sign Up to like & getrecommendations! Published in 2023 at "Circulation research"
DOI: 10.1161/circresaha.123.321673
Abstract: Numerous clinical studies have revealed the utility of circulating AM (adrenomedullin) or MR-proAM (mid-regional proAM 45-92) as an effective prognostic and diagnostic biomarker for a variety of cardiovascular-related pathophysiologies. Thus, there is strong supporting evidence… read more here.
Keywords: cardiovascular system; adrenomedullin signaling; potential adrenomedullin; clinical potential ... See more keywords
Sphingolipid metabolism and signaling in cardiovascular diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.915961
Abstract: Sphingolipids are a structural component of the cell membrane, derived from sphingosine, an amino alcohol. Its sphingoid base undergoes various types of enzymatic transformations that lead to the formation of biologically active compounds, which play… read more here.
Keywords: sphingolipid metabolism; cardiovascular diseases; metabolism signaling; signaling cardiovascular ... See more keywords