A functional drug re-purposing screening identifies carfilzomib as a drug preventing 17β-estradiol: ERα signaling and cell proliferation in breast cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.07.027
Abstract: Most cases of breast cancer (BC) are estrogen receptor α-positive (ERα+) at diagnosis. The presence of ERα drives the therapeutic approach for this disease, which often consists of endocrine therapy (ET). 4OH-Tamoxifen and faslodex (i.e.,… read more here.
Keywords: cell proliferation; breast cancer; drug; signaling cell ... See more keywords
Cotargeting AR signaling and cell cycle: A randomized phase II study of androgen deprivation therapy with or without palbociclib in RB-positive metastatic hormone sensitive prostate cancer (mHSPC).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.6_suppl.251
Abstract: 251Background: Palbociclib, a CDK4/6 inhibitor, blocked proliferation and promoted G1 arrest in an Rb and Cyclin D dependent manner in preclinical models of HSPC. Alterations in this pathway contribute to the development of CRPC. We… read more here.
Keywords: cell cycle; signaling cell; cotargeting signaling; therapy ... See more keywords
NFκB signaling in T cell memory
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1129191
Abstract: Memory T cells play an essential role in protecting against infectious diseases and cancer and contribute to autoimmunity and transplant rejection. Understanding how they are generated and maintained in the context of infection or vaccination… read more here.
Keywords: cell; infection; cell memory; memory ... See more keywords
Editorial: Emerging Mechanisms in Neuronal Signaling: From Cell Biology to Pathogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.00257
Abstract: Departamento de Quimica Biologica “Ranwel Caputto”, Facultad de Ciencias Quimicas, CONICET Center for Research in Biological Chemistry, National University of Cordoba (CIQUIBIC), Cordoba, Argentina, Departamento de Biología, Bioquímica y Farmacia, CONICETInstituto de Investigaciones Bioquímicas de… read more here.
Keywords: neuronal signaling; signaling cell; mechanisms neuronal; editorial emerging ... See more keywords