Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis
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DOI: 10.1002/dvdy.555
Abstract: Frem1 has been linked to human face shape variation, dysmorphology, and malformation, but little is known about its regulation and biological role in facial development. read more here.
Keywords: hedgehog signaling; activity regulated; sonic hedgehog; frem1 activity ... See more keywords
Augmentation of bone morphogenetic protein signaling in cranial neural crest cells in mice deforms skull base due to premature fusion of intersphenoidal synchondrosis
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DOI: 10.1002/dvg.23509
Abstract: Craniofacial anomalies (CFAs) are a diverse group of disorders affecting the shapes of the face and the head. Malformation of the cranial base in humans leads CFAs, such as midfacial hypoplasia and craniosynostosis. These patients… read more here.
Keywords: premature fusion; fusion; morphogenetic protein; bone morphogenetic ... See more keywords