NMR assignments of the N-terminal signaling domain of the TonB-dependent outer membrane transducer PupB
Sign Up to like & getrecommendations! Published in 2018 at "Biomolecular NMR Assignments"
DOI: 10.1007/s12104-017-9785-0
Abstract: Outer membrane TonB-dependent transducers (TBDTs) actively transport ferric siderophore complexes from the extracellular environment into Gram-negative bacteria. They also participate in a cell-surface signaling regulatory pathway that results in upregulation of the transducer itself, in… read more here.
Keywords: tonb dependent; nmr assignments; outer membrane; terminal signaling ... See more keywords
Distinct functions of CAR-T cells possessing a dectin-1 intracellular signaling domain.
Sign Up to like & getrecommendations! Published in 2021 at "Gene therapy"
DOI: 10.1038/s41434-021-00257-7
Abstract: Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated remarkable efficacies in treating hematopoietic malignancies, but not in the solid tumors. Incorporating costimulatory signaling domains, such as ICOS or 4-1BB, can positively influence CAR-T cell… read more here.
Keywords: solid tumors; dectin; signaling domain; car cells ... See more keywords
Abstract 1788: A novel costimulatory signaling domain for chimeric antigen receptor-engineering
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1788
Abstract: Chimeric antigen receptor (CAR)-engineered adoptive cell therapy has demonstrated a feasible, attractive “off-the-shelf” approach against various malignancies. Success of CAR-engineered cell therapy depends primarily on providing optimized costimulatory signals capable of achieving robust cell proliferation,… read more here.
Keywords: antigen receptor; signaling domain; chimeric antigen; car ... See more keywords