ADAM8 signaling drives neutrophil migration and ARDS severity
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DOI: 10.1172/jci.insight.149870
Abstract: Acute respiratory distress syndrome (ARDS) results in catastrophic lung failure and has an urgent, unmet need for improved early recognition and therapeutic development. Neutrophil influx is a hallmark of ARDS and is associated with the… read more here.
Keywords: migration ards; drives neutrophil; severity; neutrophil migration ... See more keywords
GM‐CSF suppresses antioxidant signaling and drives IL‐1β secretion through NRF2 downregulation
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DOI: 10.15252/embr.202154226
Abstract: GM‐CSF is a potent inflammatory cytokine regulating myeloid cell differentiation, hematopoiesis, and various other functions. It is functionally associated with a number of inflammatory pathologies including rheumatoid arthritis and inflammatory bowel disease. GM‐CSF has been… read more here.
Keywords: csf; antioxidant signaling; suppresses antioxidant; secretion ... See more keywords