Decoding Calcium Signaling Dynamics during Drosophila Wing Disc Development.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.01.007
Abstract: The robust specification of organ development depends on coordinated cell-cell communication. This process requires signal integration among multiple pathways, relying on second messengers such as calcium ions. Calcium signaling encodes a significant portion of the… read more here.
Keywords: decoding calcium; calcium; signaling dynamics; calcium signaling ... See more keywords
Live Visualization of ERK Activity in the Mouse Blastocyst Reveals Lineage-Specific Signaling Dynamics.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.09.030
Abstract: FGF/ERK signaling is crucial for the patterning and proliferation of cell lineages that comprise the mouse blastocyst. However, ERK signaling dynamics have never been directly visualized in live embryos. To address whether differential signaling is… read more here.
Keywords: mouse blastocyst; erk activity; signaling dynamics; cell ... See more keywords
Characteristic ERK1/2 signaling dynamics distinguishes necroptosis from apoptosis
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.103074
Abstract: Summary ERK1/2 involvement in cell death remains unclear, although many studies have demonstrated the importance of ERK1/2 dynamics in determining cellular responses. To untangle how ERK1/2 contributes to two cell death programs, we investigated ERK1/2… read more here.
Keywords: apoptosis; necroptosis; erk1; signaling dynamics ... See more keywords
Signaling Dynamics Regulating Crosstalks between T-Cell Activation and Immune Checkpoints.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2020.12.001
Abstract: Immune checkpoint inhibitors (ICIs) targeting cytotoxic T lymphocyte-associated protein-4 (CTLA-4) and programmed cell death protein-1 (PD-1) have been hailed as major advances in cancer therapeutics; however, in many cancers response rates remain low. Extensive research… read more here.
Keywords: cell activation; regulating crosstalks; dynamics regulating; signaling dynamics ... See more keywords
Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-27398-y
Abstract: Dynamic change in subcellular localization of signaling proteins is a general concept that eukaryotic cells evolved for eliciting a coordinated response to stimuli. Mass spectrometry-based proteomics in combination with subcellular fractionation can provide comprehensive maps… read more here.
Keywords: phospho signaling; spatial proteomics; reveals phospho; proteomics reveals ... See more keywords
On the inference of ERK signaling dynamics from protein biosensor measurements.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-10-0476
Abstract: The extracellular signal-regulated kinase (ERK) signaling pathway plays prominent roles in cell growth, proliferation, and differentiation. ERK signaling is dynamic, involving phosphorylation/dephosphorylation, nucleocytoplasmic shuttling, and interactions with scores of protein substrates in the cytosol and… read more here.
Keywords: erk signaling; inference erk; erk; dynamics protein ... See more keywords
Control of Gαq signaling dynamics and GPCR cross-talk by GRKs
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq3363
Abstract: Numerous processes contribute to the regulation of G protein–coupled receptors (GPCRs), but relatively little is known about rapid mechanisms that control signaling on the seconds time scale or regulate cross-talk between receptors. Here, we reveal… read more here.
Keywords: cross talk; cross; signaling dynamics; control signaling ... See more keywords
NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop
Sign Up to like & getrecommendations! Published in 2019 at "Science Signaling"
DOI: 10.1126/scisignal.aau3568
Abstract: The kinase IRAK1 senses the cytokine load to prevent overstimulation of the immune system. Keeping a check on the infection response The innate immune system responds to various cytokines and other “danger signals” that occur… read more here.
Keywords: immune; system; response; loop ... See more keywords
NfκB signaling dynamics and their target genes differ between mouse blood cell types and induce distinct cell behavior.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021012918
Abstract: Cells can use signaling pathway activity over time (i.e., dynamics) to control cell fates. However, little is known about the potential existence and function of signaling dynamics in primary hematopoietic stem and progenitor cells (HSPCs).… read more here.
Keywords: dynamics target; signaling dynamics; blood; cell ... See more keywords
From spikes to intercellular waves: Tuning intercellular calcium signaling dynamics modulates organ size control
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1009543
Abstract: Information flow within and between cells depends significantly on calcium (Ca2+) signaling dynamics. However, the biophysical mechanisms that govern emergent patterns of Ca2+ signaling dynamics at the organ level remain elusive. Recent experimental studies in… read more here.
Keywords: spikes intercellular; ca2 signaling; size; ca2 ... See more keywords
Signaling Dynamics of TSHR-Specific CAR-T Cells Revealed by FRET-Based Biosensors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.845319
Abstract: Although most patients with thyroid cancers have good prognosis and long-term survival, some patients are refractory to traditional therapeutic approaches and face a high risk of mortality. CAR-T therapy provides an attractive strategy to treat… read more here.
Keywords: car; car cells; fret based; thyroid cancers ... See more keywords