MYO6 Regulates Spatial Organization of Signaling Endosomes Driving AKT Activation and Actin Dynamics
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.05.048
Abstract: Summary APPL1- and RAB5-positive signaling endosomes play a crucial role in the activation of AKT in response to extracellular stimuli. Myosin VI (MYO6) and two of its cargo adaptor proteins, GIPC and TOM1/TOM1L2, localize to… read more here.
Keywords: spatial organization; activation; myo6 regulates; signaling endosomes ... See more keywords
Retrograde signaling via axonal transport through signaling endosomes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2019.10.001
Abstract: Neurons extend axons far from cell bodies, and retrograde communications from distal axons to cell bodies and/or dendrites play critical roles in the development and maintenance of neuronal circuits. In neurotrophin signaling, the retrograde axonal… read more here.
Keywords: neurotrophin signaling; retrograde signaling; signaling endosomes; axonal transport ... See more keywords
A spatially and functionally distinct pool of TORC1 defines signaling endosomes in yeast
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1580107
Abstract: ABSTRACT The evolutionarily conserved target of rapamycin complex 1 (TORC1) regulates cell growth in a homeostatic manner by tuning anabolic and catabolic processes in response to nutritional and hormonal cues. Interestingly, rather than being localized… read more here.
Keywords: torc1; distinct pool; spatially functionally; functionally distinct ... See more keywords