The pleiotropic vegetative and sexual development phenotypes of Neurospora crassa arise from double mutants of the calcium signaling genes plc-1, splA2, and cpe-1
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DOI: 10.1007/s00294-017-0682-y
Abstract: We investigated phenotypes of the double mutants of the calcium (Ca2+) signaling genes plc-1, splA2, and cpe-1 encoding for a phospholipase C1 (PLC-1), a secretory phospholipase A2 (sPLA2), and a Ca2+/H+ exchanger (CPE-1), respectively, to… read more here.
Keywords: signaling genes; double mutants; mutants calcium; plc spla2 ... See more keywords
Burden of rare deleterious variants in WNT signaling genes among 511 myelomeningocele patients
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DOI: 10.1371/journal.pone.0239083
Abstract: Genes in the noncanonical WNT signaling pathway controlling planar cell polarity have been linked to the neural tube defect myelomeningocele. We hypothesized that some genes in the WNT signaling network have a higher mutational burden… read more here.
Keywords: wnt signaling; signaling genes; deleterious variants; 511 myelomeningocele ... See more keywords
Profile of differentially expressed Toll-like receptor signaling genes in the natural killer cells of patients with Sézary syndrome
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DOI: 10.18632/oncotarget.21006
Abstract: Sézary syndrome (SS), an aggressive and leukemic form of cutaneous T-cell lymphoma, usually results in shortened survival. Improving innate immunity in SS by targeting natural killer (NK) cells with Toll-like receptor (TLR) agonists could be… read more here.
Keywords: toll like; zary syndrome; signaling genes; natural killer ... See more keywords
Dysregulation of Synaptic Signaling Genes Is Involved in Biology of Uterine Leiomyoma
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DOI: 10.3390/genes12081179
Abstract: Uterine leiomyomas are tumors, which are hormone driven and originate from the smooth muscle layer of the uterine wall. In addition to known genes in leiomyoma pathogenesis, recent approaches also highlight epigenetic malfunctions as an… read more here.
Keywords: genes involved; signaling genes; synaptic signaling; dysregulation ... See more keywords
Role of CGRP in Neuroimmune Interaction via NF-κB Signaling Genes in Glial Cells of Trigeminal Ganglia
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DOI: 10.3390/ijms21176005
Abstract: Activation of the trigeminal system causes the release of various neuropeptides, cytokines, and other immune mediators. Calcitonin gene-related peptide (CGRP), which is a potent algogenic mediator, is expressed in the peripheral sensory neurons of trigeminal… read more here.
Keywords: signaling genes; glial cells; cgrp; via signaling ... See more keywords
Genome-wide analysis of the strigolactone biosynthetic and signaling genes in grapevine and their response to salt and drought stresses
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DOI: 10.7717/peerj.13551
Abstract: Strigolactones (SLs) are a novel class of plant hormones that play critical roles in regulating various developmental processes and stress tolerance. Although the SL biosynthetic and signaling genes were already determined in some plants such… read more here.
Keywords: salt drought; signaling genes; drought stresses; biosynthetic signaling ... See more keywords