KIF5B-RET Oncoprotein Signals through a Multi-kinase Signaling Hub.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.08.037
Abstract: Gene fusions are increasingly recognized as important cancer drivers. The KIF5B-RET gene has been identified as a primary driver in a subset of lung adenocarcinomas. Targeting human KIF5B-RET to epithelia in Drosophila directed multiple aspects… read more here.
Keywords: kif5b ret; ret oncoprotein; signaling hub; oncoprotein signals ... See more keywords
The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent protein–protein interactions
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0348-3
Abstract: Abstract14-3-3 proteins are a family of structurally similar phospho-binding proteins that regulate essentially every major cellular function. Decades of research on 14-3-3s have revealed a remarkable network of interacting proteins that demonstrate how 14-3-3s integrate… read more here.
Keywords: protein; protein protein; stress adaptive; context dependent ... See more keywords
Ubiquitylation in plants: signaling hub for the integration of environmental signals
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/ery165
Abstract: A fundamental question in biology is how organisms integrate the plethora of environmental cues that they perceive to trigger a co-ordinated response. The regulation of protein stability, which is largely mediated by the ubiquitin-proteasome system… read more here.
Keywords: signaling pathways; system; plants signaling; environmental signals ... See more keywords
P-Rex1 Signaling Hub in Lower Grade Glioma Patients, Found by In Silico Data Mining, Correlates With Reduced Survival and Augmented Immune Tumor Microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.922025
Abstract: Systematic analysis of tumor transcriptomes, combined with deep genome sequencing and detailed clinical assessment of hundreds of patients, constitutes a powerful strategy aimed to identify potential biomarkers and therapeutic targets to guide personalized treatments. Oncogenic… read more here.
Keywords: grade glioma; reduced survival; signaling hub; tumor ... See more keywords
The Sugar-Signaling Hub: Overview of Regulators and Interaction with the Hormonal and Metabolic Network
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19092506
Abstract: Plant growth and development has to be continuously adjusted to the available resources. Their optimization requires the integration of signals conveying the plant metabolic status, its hormonal balance, and its developmental stage. Many investigations have… read more here.
Keywords: hub overview; overview regulators; sugar signaling; metabolic ... See more keywords