Glycosphingolipids within membrane contact sites influence their function as signaling hubs in neurodegenerative diseases.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13605
Abstract: Intracellular organelles carry out many of their functions by engaging in extensive inter-organellar communication through specialized membrane contact sites (MCSs) formed where two organelles tether to each other or to the plasma membrane without fusing.… read more here.
Keywords: contact sites; membrane contact; signaling hubs; membrane ... See more keywords
The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles
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DOI: 10.1007/s12551-021-00836-3
Abstract: Muscle specific signaling has been shown to originate from myofilaments and their associated cellular structures, including the sarcomeres, costameres or the cardiac intercalated disc. Two signaling hubs that play important biomechanical roles for cardiac and/or… read more here.
Keywords: n2b n2a; muscle; signaling hubs; n2a regions ... See more keywords
Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity.
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DOI: 10.1016/j.tcb.2019.08.008
Abstract: Lysosomes are sites of active metabolism in a cell. They contain various hydrolases that degrade extracellular and intracellular materials during endocytosis and autophagy, respectively. In addition to their long-recognized roles in degradation and recycling, emerging… read more here.
Keywords: metabolic sensing; hubs metabolic; longevity; lysosomes signaling ... See more keywords
Mitochondria as Cellular and Organismal Signaling Hubs.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of cell and developmental biology"
DOI: 10.1146/annurev-cellbio-120420-015303
Abstract: Mitochondria are traditionally known as the powerhouse of the cell, but their functions extend far beyond energy production. They are vital in cellular and organismal pathways that direct metabolism, stress responses, immunity, and cellular fate.… read more here.
Keywords: cellular organismal; cell; organismal signaling; mitochondria cellular ... See more keywords