The role of dysregulated PI3Kdelta signaling in human autoimmunity *
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DOI: 10.1111/imr.13067
Abstract: Better treatment of autoimmune diseases requires an improved understanding of the cellular and molecular mechanisms that lead to the breakdown of immune tolerance. The discovery of individuals with germline mutations in PIK3CD (which encodes the… read more here.
Keywords: role dysregulated; pi3kdelta signaling; autoimmunity; dysregulated pi3kdelta ... See more keywords
Functional links between Disabled‐2 Ser723 phosphorylation and thrombin signaling in human platelets
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13785
Abstract: Essentials Disabled‐2 (Dab2) phosphorylation status in thrombin signaling of human platelet was investigated. Ser723 was the major Dab2 phosphorylation site in human platelets stimulated by thrombin. Dab2 S723 phosphorylation (pS723) caused the dissociation of Dab2‐CIN85… read more here.
Keywords: human platelets; phosphorylation; dab2; signaling human ... See more keywords
AR Signaling in Human Malignancies: Prostate Cancer and Beyond
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DOI: 10.3390/cancers10010022
Abstract: The notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in… read more here.
Keywords: malignancies prostate; prostate cancer; human malignancies; cancer beyond ... See more keywords
Shikonin Derivatives Inhibit Inflammation Processes and Modulate MAPK Signaling in Human Healthy and Osteoarthritis Chondrocytes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23063396
Abstract: Osteoarthritis (OA) is the most common joint disorder and is characterized by the degeneration of articular cartilage. To develop new therapeutic approaches, we investigated the effect of shikonin derivatives on inflammation, MMP expression, and the… read more here.
Keywords: shikonin derivatives; mapk signaling; human healthy; osteoarthritis ... See more keywords