Androgen Receptor Signaling Inhibitors in Nonmetastatic Castration-resistant Prostate Cancer and Risk of Cardiovascular Toxicity: All That Glitters Isn't Gold.
Sign Up to like & getrecommendations! Published in 2020 at "European urology"
DOI: 10.1016/j.eururo.2020.07.036
Abstract: Androgen receptor signaling inhibitors have a metastasis-free survival benefit for men with nonmetastatic castration-resistant prostate cancer. The latest updates for the PROSPER, SPARTAN, and ARAMIS trials also demonstrate an overall survival benefit. However, the cardiovascular… read more here.
Keywords: signaling inhibitors; nonmetastatic castration; castration resistant; receptor signaling ... See more keywords
TET1 inhibits EMT of ovarian cancer cells through activating Wnt/β-catenin signaling inhibitors DKK1 and SFRP2.
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2017.08.010
Abstract: OBJECTIVE Epithelial ovarian cancer (EOC) is the deadliest type of ovarian cancer, but the mechanisms contributing to its tumorigenesis are not well understood. Herein, we will elucidate the role of Ten-eleven translocation 1 (TET1) in… read more here.
Keywords: catenin signaling; signaling inhibitors; ovarian cancer; wnt catenin ... See more keywords
Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076733
Abstract: In a continuous search for the improvement of antitumor therapies, the inhibition of the Wnt signaling pathway has been recognized as a promising target. The altered functioning of the Wnt signaling in human tumors points… read more here.
Keywords: role; wnt pathway; signaling inhibitors; wnt ... See more keywords
Neoadjuvant Androgen Receptor Signaling Inhibitors before Radical Prostatectomy for Non-Metastatic Advanced Prostate Cancer: A Systematic Review
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm13040641
Abstract: (1) Background: Several phase II studies, including randomized controlled trials (RCTs), assessed the efficacy of adding androgen receptor signaling inhibitors (ARSIs) to androgen deprivation therapy (ADT) as a neoadjuvant treatment in patients treated with radical… read more here.
Keywords: prostate cancer; androgen receptor; receptor signaling; signaling inhibitors ... See more keywords
Carbohydrate-Small Molecule Hybrids as Lead Compounds Targeting IL-6 Signaling
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020677
Abstract: In the past 25 years, a number of efforts have been made toward the development of small molecule interleukin-6 (IL-6) signaling inhibitors, but none have been approved to date. Monosaccharides are a diverse class of… read more here.
Keywords: small molecule; molecule; signaling inhibitors; carbohydrate small ... See more keywords