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Toll-like receptor-4 signaling mediates inflammation and tissue injury in diabetic nephropathy

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0 Published in 2017 at "Journal of Nephrology"

DOI: 10.1007/s40620-017-0432-8

Abstract: Toll-like receptors (TLRs) are a class of receptors of the innate immune system which detect pathogen-associated and danger-associated molecular patterns in order to initiate an inflammatory response. TLR2 and TLR4 downward signaling causes the production… read more here.

Keywords: toll like; signaling mediates; like receptor; diabetic nephropathy ... See more keywords

Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.

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0 Published in 2019 at "Cell reports"

DOI: 10.1016/j.celrep.2019.03.078

Abstract: Dendritic inhibitory synapses are most efficient in modulating excitatory inputs localized on the same dendrite, but it is unknown whether their location is random or regulated. Here, we show that the formation of inhibitory synapses… read more here.

Keywords: mediates local; signaling mediates; excitatory; endocannabinoid signaling ... See more keywords

Glutamate signaling mediates C. elegans behavioral plasticity to pathogens

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1 Published in 2022 at "iScience"

DOI: 10.1016/j.isci.2022.103919

Abstract: Summary In Caenorhabditis elegans, sensory neurons mediate behavioral response to pathogens. However, how C. elegans intergrades these sensory signals via downstream neuronal and molecular networks remains largely unknown. Here, we report that glutamate transmission mediates… read more here.

Keywords: mediates elegans; glutamate signaling; signaling mediates; behavioral plasticity ... See more keywords

STAT3 signaling mediates tumour resistance to EGFR targeted therapeutics

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0 Published in 2017 at "Molecular and Cellular Endocrinology"

DOI: 10.1016/j.mce.2017.01.010

Abstract: Several EGFR inhibitors are currently undergoing clinical assessment or are approved for the clinical management of patients with varying tumour types. However, treatment often results in a lack of response in many patients. The majority… read more here.

Keywords: egfr targeted; tumour resistance; signaling mediates; resistance ... See more keywords

Hepatocyte Signaling Mediates a Prometastatic Niche in the Liver.

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0 Published in 2019 at "Cancer discovery"

DOI: 10.1158/2159-8290.cd-rw2019-035

Abstract: Hepatocyte-mediated inflammatory signaling is critical for liver metastasis. read more here.

Keywords: hepatocyte; prometastatic niche; hepatocyte signaling; liver ... See more keywords