Calcium Signaling and Metabolic Reprogramming in Cancer: Mechanisms and Therapeutic Implications.
Sign Up to like & getrecommendations! Published in 2025 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a041764
Abstract: Calcium is essential for cellular homeostasis, orchestrating a vast array of physiological processes through tightly regulated storage, flux, and signaling pathways. Dysregulation of calcium homeostasis disrupts these finely tuned processes, leading to aberrant signaling that… read more here.
Keywords: cancer; metabolic reprogramming; calcium; reprogramming cancer ... See more keywords
Abstract 525: A comprehensive approach: Copper chelation therapy modulates epigenetic, kinase signaling and metabolic pathways in diffuse midline gliomas (DMG)
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-525
Abstract: Diffuse Midline Gliomas (DMG) are incurable pediatric brain tumors driven by histone mutation H3K27M, globally reducing H3K27 trimethylation altering the epigenome and deregulating gene expression. These mutations often partner with and are strongly integrated into… read more here.
Keywords: dmg; epigenetic kinase; copper; kinase signaling ... See more keywords
Cooperative Instruction of Signaling and Metabolic Pathways on the Epigenetic Landscape
Sign Up to like & getrecommendations! Published in 2018 at "Molecules and Cells"
DOI: 10.14348/molcells.2018.0076
Abstract: Cells cope with diverse intrinsic and extrinsic stimuli in order to make adaptations for survival. The epigenetic landscape plays a crucial role in cellular adaptation, as it integrates the information generated from stimuli. Signaling pathways… read more here.
Keywords: instruction signaling; metabolic pathways; epigenetic landscape; landscape ... See more keywords
Role of Biliverdin Reductase A in the Regulation of Insulin Signaling in Metabolic and Neurodegenerative Diseases: An Update
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105574
Abstract: Insulin signaling is a conserved pathway that orchestrates glucose and lipid metabolism, energy balance, and inflammation, and its dysregulation compromises the homeostasis of multiple systems. Insulin resistance is a shared hallmark of several metabolic diseases,… read more here.
Keywords: role; signaling metabolic; regulation insulin; biliverdin reductase ... See more keywords