De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia
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DOI: 10.1038/s41467-018-04180-1
Abstract: Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL) rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remains unclear. Using a retroviral acute myeloid mouse leukemia model, we demonstrate… read more here.
Keywords: signaling mutations; clonal evolution; kmt2a mllt3; kmt2a ... See more keywords