Regulated Stochasticity in a Bacterial Signaling Network Permits Tolerance to a Rapid Environmental Change
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.11.051
Abstract: (Cell 173, 196–207.e1–e14; March 22, 2018) We discovered that in Figure 3A of our paper, the four rows of transcriptomics data (labeled Log2 ssRNA Value) were mistakenly shifted slightly to the right relative to the… read more here.
Keywords: signaling network; regulated stochasticity; bacterial signaling; permits tolerance ... See more keywords
Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry
Sign Up to like & getrecommendations! Published in 2017 at "Nature biotechnology"
DOI: 10.1038/nbt.3770
Abstract: Signaling networks are key regulators of cellular function. Although the concentrations of signaling proteins are perturbed in disease states, such as cancer, and are modulated by drug therapies, our understanding of how such changes shape… read more here.
Keywords: signaling network; mass cytometry; abundance; signaling proteins ... See more keywords
CmP Signaling Network Leads to Identification of Prognostic Biomarkers for Triple-Negative Breast Cancer in Caucasian Women.
Sign Up to like & getrecommendations! Published in 2022 at "Genetic testing and molecular biomarkers"
DOI: 10.1089/gtmb.2021.0221
Abstract: Objective: Triple-negative breast cancer (TNBC) constitutes ∼15% of all diagnosed invasive breast cancer cases with limited options for treatment since immunotherapies that target ER, PR, and HER2 receptors are ineffective. Progesterone (PRG) can induce its… read more here.
Keywords: signaling network; breast cancer; breast; biology ... See more keywords
SIGNOR 3.0, the SIGnaling network open resource 3.0: 2022 update
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac883
Abstract: Abstract The SIGnaling Network Open Resource (SIGNOR 3.0, https://signor.uniroma2.it) is a public repository that captures causal information and represents it according to an ‘activity-flow’ model. SIGNOR provides freely-accessible static maps of causal interactions that can… read more here.
Keywords: signaling network; network open; open resource; signor ... See more keywords
Drug discovery for psychiatric disorders using high-content single-cell screening of signaling network responses ex vivo
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aau9093
Abstract: High-content functional screening of primary patient blood cells reveals repurposed psychiatric drug candidates. There is a paucity of efficacious new compounds to treat neuropsychiatric disorders. We present a novel approach to neuropsychiatric drug discovery based… read more here.
Keywords: signaling network; drug; network responses; drug discovery ... See more keywords
Effective Combination Therapies for B-cell Lymphoma Predicted by a Virtual Disease Model.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-0476
Abstract: The complexity of cancer signaling networks limits the efficacy of most single-agent treatments and brings about challenges in identifying effective combinatorial therapies. In this study, we used chronic active B-cell receptor (BCR) signaling in diffuse… read more here.
Keywords: signaling network; combination therapies; effective combination; model ... See more keywords
Abstract IA06: Targeting the ERK-MYC signaling network for the treatment of KRAS-mutant cancers
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-ia06
Abstract: KRAS is mutationally activated in 95% of pancreatic ductal adenocarcinomas (PDAC) and essential for maintenance of PDAC tumorigenic growth. The recent clinical evaluation of inhibitors of one KRAS mutant (KRASG12C) supports the therapeutic value of… read more here.
Keywords: signaling network; kras mutant; myc; treatment ... See more keywords
Predictive data-driven modeling of C-terminal tyrosine function in the EGFR signaling network
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202201466
Abstract: The site-specific function of EGFR’s C-terminal tyrosines is interrogated by phosphotyrosine phosphoproteomics to build a data-driven model that links cell response to signaling nodes and elucidates novel associations in the EGFR signaling network. read more here.
Keywords: signaling network; function egfr; data driven; egfr signaling ... See more keywords
Role of Mitochondria in the Redox Signaling Network and Its Outcomes in High Impact Inflammatory Syndromes
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.568305
Abstract: Inflammation is associated with the release of soluble mediators that drive cellular activation and migration of inflammatory leukocytes to the site of injury, together with endothelial expression of adhesion molecules, and increased vascular permeability. It… read more here.
Keywords: signaling network; response; inflammation; inflammatory ... See more keywords
Zinc’s Association with the CmPn/CmP Signaling Network in Breast Cancer Tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12111672
Abstract: It is well-known that serum and cellular concentrations of zinc are altered in breast cancer patients. Specifically, there are notable zinc hyper-aggregates in breast tumor cells when compared to normal mammary epithelial cells. However, the… read more here.
Keywords: zinc; signaling network; breast cancer; cmpn cmp ... See more keywords
An Unbiased Approach to Mapping the Signaling Network of the Pseudorabies Virus US3 Protein
Sign Up to like & getrecommendations! Published in 2020 at "Pathogens"
DOI: 10.3390/pathogens9110916
Abstract: The US3 serine/threonine protein kinase is conserved among the alphaherpesvirus family and represents an important virulence factor. US3 plays a role in viral nuclear egress, induces dramatic alterations of the cytoskeleton, represses apoptosis, enhances gene… read more here.
Keywords: protein; signaling network; unbiased approach; us3 protein ... See more keywords