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   Articles with "signaling network" as a keyword



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Regulated Stochasticity in a Bacterial Signaling Network Permits Tolerance to a Rapid Environmental Change

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recommendations! Published in 2018 at "Cell"

DOI: 10.1016/j.cell.2018.11.051

Abstract: (Cell 173, 196–207.e1–e14; March 22, 2018) We discovered that in Figure 3A of our paper, the four rows of transcriptomics data (labeled Log2 ssRNA Value) were mistakenly shifted slightly to the right relative to the… read more here.

Keywords: signaling network; regulated stochasticity; bacterial signaling; permits tolerance ... See more keywords

Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry

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recommendations! Published in 2017 at "Nature biotechnology"

DOI: 10.1038/nbt.3770

Abstract: Signaling networks are key regulators of cellular function. Although the concentrations of signaling proteins are perturbed in disease states, such as cancer, and are modulated by drug therapies, our understanding of how such changes shape… read more here.

Keywords: signaling network; mass cytometry; abundance; signaling proteins ... See more keywords

CmP Signaling Network Leads to Identification of Prognostic Biomarkers for Triple-Negative Breast Cancer in Caucasian Women.

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recommendations! Published in 2022 at "Genetic testing and molecular biomarkers"

DOI: 10.1089/gtmb.2021.0221

Abstract: Objective: Triple-negative breast cancer (TNBC) constitutes ∼15% of all diagnosed invasive breast cancer cases with limited options for treatment since immunotherapies that target ER, PR, and HER2 receptors are ineffective. Progesterone (PRG) can induce its… read more here.

Keywords: signaling network; breast cancer; breast; biology ... See more keywords

Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior

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recommendations! Published in 2024 at "Genetics"

DOI: 10.1093/genetics/iyae141

Abstract: Abstract Neuropeptides are abundant signaling molecules that control neuronal activity and behavior in all animals. Owing in part to its well-defined and compact nervous system, Caenorhabditis elegans has been one of the primary model organisms… read more here.

Keywords: signaling network; neuropeptide signaling; network caenorhabditis; caenorhabditis elegans ... See more keywords

SIGNOR 3.0, the SIGnaling network open resource 3.0: 2022 update

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac883

Abstract: Abstract The SIGnaling Network Open Resource (SIGNOR 3.0, https://signor.uniroma2.it) is a public repository that captures causal information and represents it according to an ‘activity-flow’ model. SIGNOR provides freely-accessible static maps of causal interactions that can… read more here.

Keywords: signaling network; network open; open resource; signor ... See more keywords

Drug discovery for psychiatric disorders using high-content single-cell screening of signaling network responses ex vivo

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recommendations! Published in 2019 at "Science Advances"

DOI: 10.1126/sciadv.aau9093

Abstract: High-content functional screening of primary patient blood cells reveals repurposed psychiatric drug candidates. There is a paucity of efficacious new compounds to treat neuropsychiatric disorders. We present a novel approach to neuropsychiatric drug discovery based… read more here.

Keywords: signaling network; drug; network responses; drug discovery ... See more keywords

Effective Combination Therapies for B-cell Lymphoma Predicted by a Virtual Disease Model.

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recommendations! Published in 2017 at "Cancer research"

DOI: 10.1158/0008-5472.can-16-0476

Abstract: The complexity of cancer signaling networks limits the efficacy of most single-agent treatments and brings about challenges in identifying effective combinatorial therapies. In this study, we used chronic active B-cell receptor (BCR) signaling in diffuse… read more here.

Keywords: signaling network; combination therapies; effective combination; model ... See more keywords

Abstract IA06: Targeting the ERK-MYC signaling network for the treatment of KRAS-mutant cancers

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recommendations! Published in 2023 at "Molecular Cancer Research"

DOI: 10.1158/1557-3125.ras23-ia06

Abstract: KRAS is mutationally activated in 95% of pancreatic ductal adenocarcinomas (PDAC) and essential for maintenance of PDAC tumorigenic growth. The recent clinical evaluation of inhibitors of one KRAS mutant (KRASG12C) supports the therapeutic value of… read more here.

Keywords: signaling network; kras mutant; myc; treatment ... See more keywords

Multiomic Analyses of Erythropoiesis and Anemia Mechanisms Reveal a Signaling Network with Converging Cytokine and Sphingolipid Inflammatory Pathways

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-203850

Abstract: Recent studies from our group have established a paradigm where GATA factors control erythropoiesis by regulating the expression of transporters and biosynthetic enzymes, which dictates intracellular levels of small molecules, including heme, metal ions, and… read more here.

Keywords: signaling network; epo signaling; inflammatory; epo ... See more keywords
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Predictive data-driven modeling of C-terminal tyrosine function in the EGFR signaling network

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recommendations! Published in 2023 at "Life Science Alliance"

DOI: 10.26508/lsa.202201466

Abstract: The site-specific function of EGFR’s C-terminal tyrosines is interrogated by phosphotyrosine phosphoproteomics to build a data-driven model that links cell response to signaling nodes and elucidates novel associations in the EGFR signaling network. read more here.

Keywords: signaling network; function egfr; data driven; egfr signaling ... See more keywords

Role of Mitochondria in the Redox Signaling Network and Its Outcomes in High Impact Inflammatory Syndromes

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recommendations! Published in 2020 at "Frontiers in Endocrinology"

DOI: 10.3389/fendo.2020.568305

Abstract: Inflammation is associated with the release of soluble mediators that drive cellular activation and migration of inflammatory leukocytes to the site of injury, together with endothelial expression of adhesion molecules, and increased vascular permeability. It… read more here.

Keywords: signaling network; response; inflammation; inflammatory ... See more keywords