Signaling networks in joint development
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24472
Abstract: Here we review studies identifying regulatory networks responsible for synovial, cartilaginous, and fibrous joint development. Synovial joints, characterized by the fluid‐filled synovial space between the bones, are found in high‐mobility regions and are the most… read more here.
Keywords: networks joint; signaling networks; development; joint development ... See more keywords
Quantification of Cell Signaling Networks Using Kinase Activity Chemosensors.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7154-1_4
Abstract: The ability to directly determine endogenous kinase activity in tissue homogenates provides valuable insights into signaling aberrations that underlie disease phenotypes. When activity data is collected across a panel of kinases, a unique "signaling fingerprint"… read more here.
Keywords: kinase activity; kinase; cell signaling; signaling networks ... See more keywords
Modulating signaling networks by CRISPR/Cas9-mediated transposable element insertion
Sign Up to like & getrecommendations! Published in 2017 at "Current Genetics"
DOI: 10.1007/s00294-017-0765-9
Abstract: In a recent past, transposable elements (TEs) were referred to as selfish genetic components only capable of copying themselves with the aim of increasing the odds of being inherited. Nonetheless, TEs have been initially proposed… read more here.
Keywords: networks crispr; crispr cas9; modulating signaling; signaling networks ... See more keywords
Proteomic characterization of MPK4 signaling network and putative substrates
Sign Up to like & getrecommendations! Published in 2019 at "Plant Molecular Biology"
DOI: 10.1007/s11103-019-00908-9
Abstract: Combining genetic engineering of MPK4 activity and quantitative proteomics, we established an in planta system that enables rapid study of MPK4 signaling networks and potential substrate proteins. Mitogen activated protein kinase 4 (MPK4) is a… read more here.
Keywords: kinase; characterization mpk4; signaling networks; mpk4 signaling ... See more keywords
Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.09.008
Abstract: Tyrosine phosphorylation regulates multi-layered signaling networks with broad implications in (patho)physiology, but high-throughput methods for functional annotation of phosphotyrosine sites are lacking. To decipher phosphotyrosine signaling directly in tissue samples, we developed a mass-spectrometry-based interaction… read more here.
Keywords: phosphotyrosine; signaling networks; tissue; phosphotyrosine sites ... See more keywords
Phosphoproteomics of Acute Cell Stressors Targeting Exercise Signaling Networks Reveal Drug Interactions Regulating Protein Secretion.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.10.001
Abstract: Exercise engages signaling networks to control the release of circulating factors beneficial to health. However, the nature of these networks remains undefined. Using high-throughput phosphoproteomics, we quantify 20,249 phosphorylation sites in skeletal muscle-like myotube cells… read more here.
Keywords: exercise signaling; cell stressors; signaling networks; stressors targeting ... See more keywords
Underground Signaling Networks
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.556
Abstract: The dorsal part of the turtle shell, or the carapace, is made of modified ribs and the vertebral column. The structure is regarded as an example of evolutionary novelties because the topographical relationships between the… read more here.
Keywords: scapula; turtle specific; turtle; signaling networks ... See more keywords
Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.05.013
Abstract: Phosphotyrosine (pTyr) signaling has evolved into a key cell-to-cell communication system. Activated receptor tyrosine kinases (RTKs) initiate several pTyr-dependent signaling networks by creating the docking sites required for the assembly of protein complexes. However, the… read more here.
Keywords: homology domains; src homology; direct phosphorylation; signaling networks ... See more keywords
Learning of signaling networks: molecular mechanisms
Sign Up to like & getrecommendations! Published in 2020 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2019.12.005
Abstract: Molecular processes of neuronal learning have been well described. However, learning mechanisms of non-neuronal cells are not yet fully understood at the molecular level. Here, we discuss molecular mechanisms of cellular learning, including conformational memory… read more here.
Keywords: molecular mechanisms; learning signaling; networks molecular; signaling networks ... See more keywords
Transducing Complex Biomolecular Interactions by Temperature-Output Artificial DNA Signaling Networks.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c05453
Abstract: The requirement of special expensive instruments for quantitative information readout has significantly restricted sustainable development, from ideation to execution, of advanced artificial networks. Here we present a step to-ward a paradigm of evolutionary signaling networks… read more here.
Keywords: temperature output; dna signaling; signaling networks;
Unraveling cell-to-cell signaling networks with chemical biology.
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2391
Abstract: Cell-to-cell signaling networks, although poorly understood, guide tissue development, regulate tissue function and may become dysregulated in disease. Chemical biologists can develop the next generation of tools to untangle these complex and dynamic networks of… read more here.
Keywords: cell; chemical biology; cell signaling; signaling networks ... See more keywords