CCAL1 enhances osteoarthritis through the NF‐κB/AMPK signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12989
Abstract: Osteoarthritis (OA) is a chronic joint disease characterized by articular cartilage degeneration and secondary osteogenesis. It has been previously demonstrated that the CCAL1 locus is the gene encoding tumor necrosis factor receptor superfamily member 11B… read more here.
Keywords: signaling pathway; enhances osteoarthritis; ccal1 enhances; ampk signaling ... See more keywords
ZIPK activates the IL‐6/STAT3 signaling pathway and promotes cisplatin resistance in gastric cancer cells
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DOI: 10.1002/2211-5463.13270
Abstract: Gastric cancer is one of the most common malignant cancers globally. Chemotherapy resistance remains a major obstacle in the treatment of gastric cancer, and the molecular mechanisms underlying drug resistance are still not well understood.… read more here.
Keywords: gastric cancer; zipk; signaling pathway; resistance ... See more keywords
Mitochondrial morphology and MAVS‐IFN1 signaling pathway in muscles of anti‐MDA5 dermatomyositis
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51311
Abstract: This study aimed to investigate mitochondrial changes and the mitochondrial antiviral‐signaling protein (MAVS)‐type I interferon (IFN1) signaling pathway in the muscles of anti‐melanoma differentiation gene 5(MDA5) dermatomyositis (DM) patients. read more here.
Keywords: pathway muscles; muscles anti; ifn1 signaling; mda5 dermatomyositis ... See more keywords
Antioxidant Cascade Nanoenzyme Antagonize Inflammatory Pain by Modulating MAPK/p‐65 Signaling Pathway
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DOI: 10.1002/advs.202206934
Abstract: Chronic pain has attracted wide interest because it is a major obstacle affecting the quality of life. Consequently, safe, efficient, and low‐addictive drugs are highly desirable. Nanoparticles (NPs) with robust anti‐oxidative stress and anti‐inflammatory properties… read more here.
Keywords: signaling pathway; mapk signaling; sfz nps; cascade nanoenzyme ... See more keywords
SOX11 regulates apoptosis and cell cycle in hepatocellular carcinoma via Wnt/β‐catenin signaling pathway
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DOI: 10.1002/bab.1718
Abstract: Hepatocellular carcinoma (HCC) is the most common type of liver cancer with high mortality. Identifying key molecules involved in the regulation of HCC development is of great clinical significance. SOX11 is a transcription factor belonging… read more here.
Keywords: hepatocellular carcinoma; hcc; catenin signaling; signaling pathway ... See more keywords
Direct moxibustion exerts an analgesic effect on cervical spondylotic radiculopathy by increasing autophagy via the Act A/Smads signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2545
Abstract: Direct moxibustion (DM) is reported to be useful for cervical spondylotic radiculopathy (CSR), but the analgesic mechanism remains unknown. Autophagy plays a protective role in neuronal apoptosis, Act A/Smads signaling pathway has been confirmed to… read more here.
Keywords: signaling pathway; act smads; cervical spondylotic; smads signaling ... See more keywords
Electroacupuncture reverses endothelial cell death and promotes angiogenesis through the VEGF/Notch signaling pathway after focal cerebral ischemia‐reperfusion injury
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2912
Abstract: Angiogenesis is an important mechanism of recovery from ischemic stroke. Recent studies have found that there is a close relationship between the VEGF/Notch pathway and angiogenesis. It is unknown whether EA can exert a brain… read more here.
Keywords: notch signaling; signaling pathway; vegf; pathway focal ... See more keywords
Apoptin‐derived peptide reverses cisplatin resistance in gastric cancer through the PI3K–AKT signaling pathway
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DOI: 10.1002/cam4.1380
Abstract: The prognosis of gastric cancer (GC) remains poor due to clinical drug resistance, and novel drugs are urgently needed. Apoptin‐derived peptide (AdP) is an antitumor polypeptide constructed in our laboratory that has been used to… read more here.
Keywords: cancer; signaling pathway; resistance; pi3k akt ... See more keywords
LncRNA‐LOC101928316 contributes to gastric cancer progression through regulating PI3K‐Akt‐mTOR signaling pathway
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DOI: 10.1002/cam4.2165
Abstract: Long noncoding RNA (lncRNA) has played the important function in regulation of various biological processes and in diagnostic value has been widely appreciated. In the present study, we have found that LOC101928316 was significantly downregulated… read more here.
Keywords: gastric cancer; mtor signaling; pi3k akt; signaling pathway ... See more keywords
Genetic variants in p53 signaling pathway genes predict chemotherapy efficacy in colorectal cancer
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DOI: 10.1002/cam4.2215
Abstract: The murine double minute‐2 gene (MDM2) was originally identified as predicting chemotherapy efficacy. However, little is known regarding the association between single nucleotide polymorphisms (SNPs) in the p53 signaling pathway and prognosis/chemotherapy sensitivity in colorectal… read more here.
Keywords: chemotherapy; p53 signaling; colorectal cancer; signaling pathway ... See more keywords
The Sonic Hedgehog signaling pathway regulates autophagy and migration in ovarian cancer
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DOI: 10.1002/cam4.4018
Abstract: The Sonic Hedgehog (SHH) signaling pathway plays an important role in various types of human cancers including ovarian cancer; however, its function and underlying mechanism in ovarian cancer are still not entirely understood. read more here.
Keywords: cancer; signaling pathway; ovarian cancer; sonic hedgehog ... See more keywords