Articles with "signaling profile" as a keyword



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A unique MC4R signaling profile for obesity-associated constitutively active variants.

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Published in 2023 at "Journal of molecular endocrinology"

DOI: 10.1530/jme-23-0008

Abstract: The human melanocortin-4 receptor plays a critical role regulating energy homeostasis. Studies on obesogenic hMC4R variants have not yet revealed how human melanocortin-4 receptor maintains body weight. Here, we identified a signaling profile for obesogenic… read more here.

Keywords: human melanocortin; melanocortin receptor; signaling profile; constitutively active ... See more keywords