Hedgehog signaling promotes angiogenesis directly and indirectly in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2020 at "Angiogenesis"
DOI: 10.1007/s10456-020-09725-x
Abstract: Introduction The inhibition of Hedgehog (Hh) signaling in pancreatic ductal adenocarcinoma (PDAC) reduces desmoplasia and promotes increased vascularity. In contrast to these findings, the Hh ligand Sonic Hedgehog (SHH) is a potent proangiogenic factor in… read more here.
Keywords: hedgehog signaling; signaling promotes; hedgehog; effect ... See more keywords
Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythroblasts
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjac001
Abstract: Abstract The aryl hydrocarbon receptor (AHR) plays an important role during mammalian embryo development. Inhibition of AHR signaling promotes the development of hematopoietic stem/progenitor cells. AHR also regulates the functional maturation of blood cells, such… read more here.
Keywords: hydrocarbon receptor; inhibition; signaling promotes; ahr ... See more keywords
Branching out underground: brassinosteroid signaling promotes lateral root development in rice
Sign Up to like & getrecommendations! Published in 2022 at "Plant Physiology"
DOI: 10.1093/plphys/kiac080
Abstract: OsHDAC1 phosphorylates the BR-response transcription factor OsBZR1, targeting it for proteasomal-mediated degradation. Consequently, the inactivation of OsGSK2 by OsHDAC1 causes OsBZR1 accumulation and increased BR signaling, which upregulates the expression of genes that promote LR… read more here.
Keywords: promotes lateral; development; underground brassinosteroid; signaling promotes ... See more keywords
Preventing RIα Phase Separation Disrupts Signaling and Promotes Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2020-130
Abstract: RIα, a regulatory subunit of protein kinase A, formed liquid droplets that concentrated cAMP. read more here.
Keywords: signaling promotes; cancer; disrupts signaling; preventing phase ... See more keywords
Wnt/β-catenin signaling promotes aging-associated hair graying in mice
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DOI: 10.18632/oncotarget.20613
Abstract: Canities is an obvious sign of aging in mouse and human, shown as hair graying. Melanocytes in the hair follicle show cyclic activity with hair cycling, which transitions from anagen, catagen to telogen. How the… read more here.
Keywords: hair graying; signaling promotes; hair; mice ... See more keywords
Gq-Mediated Arrhythmogenic Signaling Promotes Atrial Fibrillation
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020526
Abstract: Background: Atrial fibrillation (AF) is promoted by various stimuli like angiotensin II, endothelin-1, epinephrine/norepinephrine, vagal activation, or mechanical stress, all of which activate receptors coupled to G-proteins of the Gαq/Gα11-family (Gq). Besides pro-fibrotic and pro-inflammatory… read more here.
Keywords: mediated arrhythmogenic; signaling promotes; mice; atrial fibrillation ... See more keywords