Absolute Quantification of TGF-β Signaling Proteins Using Quantitative Western Blot.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2277-3_1
Abstract: Cell signaling governs the basic functions of cells by molecular interactions that involve of many proteins. The abundance of signaling proteins can directly influence cellular responses to external signal, contributing to cellular heterogeneity. Absolute quantification… read more here.
Keywords: using quantitative; absolute quantification; proteins using; signaling proteins ... See more keywords
Cortical and hippocampal expression of inflammatory and intracellular signaling proteins in aged rats submitted to aerobic and resistance physical training
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2018.06.025
Abstract: &NA; Aging is often accompanied by an increase in pro‐inflammatory markers. This inflammatory process is directly related to cellular dysfunctions that induce events such as the exacerbated activation of cell death signaling pathways. In the… read more here.
Keywords: aged rats; training; inflammatory; resistance ... See more keywords
Enrichment of oxidised peptides of oxidised allows identification of oxidized cysteine residues in signaling proteins in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.118
Abstract: Detection of oxidative post-translational modifications (ox-PTMs) of Cys residues in mammalian signaling proteins in vivo is one of the current challenges in redox biology. Ox-PTM residues labeling using maleimide switch methods coupled to mass spectrometry… read more here.
Keywords: cys; proteins vivo; biology; signaling proteins ... See more keywords
Regulation of signaling proteins in the brain by light
Sign Up to like & getrecommendations! Published in 2019 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2019.101638
Abstract: In order to study the role of signaling proteins, such as kinases and GTPases, in brain functions it is necessary to control their activity at the appropriate spatiotemporal resolution and to examine the cellular and… read more here.
Keywords: proteins activity; brain; signaling proteins; regulation signaling ... See more keywords
Intestinal Signaling of Proteins and Digestion-Derived Products Relevant to Satiety.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b02355
Abstract: Luminal nutrients stimulate enteroendocrine cells through the activation of specific receptors to release hormones that inhibit appetite and promote glucose homeostasis. While food protein is the macronutrient with the highest effect on satiety, the signaling… read more here.
Keywords: protein digestion; intestinal signaling; satiety; signaling proteins ... See more keywords
Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry
Sign Up to like & getrecommendations! Published in 2017 at "Nature biotechnology"
DOI: 10.1038/nbt.3770
Abstract: Signaling networks are key regulators of cellular function. Although the concentrations of signaling proteins are perturbed in disease states, such as cancer, and are modulated by drug therapies, our understanding of how such changes shape… read more here.
Keywords: signaling network; mass cytometry; abundance; signaling proteins ... See more keywords
IRAK1 and IRAK4 signaling proteins are dispensable in the response of human neutrophils to Mycobacterium tuberculosis infection.
Sign Up to like & getrecommendations! Published in 2019 at "FEMS microbiology letters"
DOI: 10.1093/femsle/fnz226
Abstract: The involvement of neutrophils in the host response to Mycobacterium tuberculosis (Mtb) infection is not as well recognized as the involvement of macrophages and dendritic cells. Thus, this study gives more insight on the impact… read more here.
Keywords: response; irak1 irak4; infection; signaling proteins ... See more keywords
Jasmonates: biosynthesis, metabolism, and signaling by proteins activating and repressing transcription
Sign Up to like & getrecommendations! Published in 2017 at "Journal Of Experimental Botany"
DOI: 10.1093/jxb/erw443
Abstract: The lipid-derived phytohormone jasmonate (JA) regulates plant growth, development, secondary metabolism, defense against insect attack and pathogen infection, and tolerance to abiotic stresses such as wounding, UV light, salt, and drought. JA was first identified… read more here.
Keywords: proteins activating; metabolism; biosynthesis metabolism; signaling proteins ... See more keywords
Ancestral reconstruction of duplicated signaling proteins reveals the evolution of signaling specificity
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.02.11.480122
Abstract: Gene duplication is crucial to generating novel signaling pathways during evolution. However, it remains unclear how the redundant proteins produced by gene duplication ultimately acquire new interaction specificities to establish insulated paralogous signaling pathways. Here,… read more here.
Keywords: duplicated signaling; ancestral reconstruction; reconstruction duplicated; specificity ... See more keywords
Evolutionary couplings of amino acid residues reveal structure and function of bacterial signaling proteins
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Microbiology"
DOI: 10.1111/mmi.14282
Abstract: The genomic era along with major advances in high‐throughput sequencing technology has led to a rapid expansion of the genomic and consequently the protein sequence space. Bacterial extracytoplasmic function sigma factors have emerged as an… read more here.
Keywords: protein; couplings amino; signaling proteins; structure ... See more keywords
Intrinsically disordered signaling proteins: Essential hub players in the control of stress responses in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0265422
Abstract: Cells have developed diverse mechanisms to monitor changes in their surroundings. This allows them to establish effective responses to cope with adverse environments. Some of these mechanisms have been well characterized in the budding yeast… read more here.
Keywords: intrinsically disordered; structural disorder; stress responses; signaling proteins ... See more keywords