Retinoic acid signaling regulates late stages of semicircular canal morphogenesis and otolith maintenance in the zebrafish inner ear
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.510
Abstract: The vitamin A derivative all‐trans retinoic acid (RA) regulates early stages of inner ear development. As the early disruption of the RA pathway results in profound mispatterning of the developing inner ear, this confounds analyses… read more here.
Keywords: signaling regulates; inner ear; acid signaling; retinoic acid ... See more keywords
Chloroplast-to-Nucleus Signaling Regulates MicroRNA Biogenesis in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.11.046
Abstract: As integral regulators in plant development and stress response, microRNAs (miRNAs) themselves need to be tightly regulated. Here, we show that tocopherols (vitamin E), lipid-soluble antioxidants synthesized from tyrosine in chloroplasts, positively regulate the biogenesis… read more here.
Keywords: nucleus signaling; chloroplast nucleus; microrna biogenesis; signaling regulates ... See more keywords
Neuropeptide signaling regulates the susceptibility of developing C. elegans to anoxia
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.12.006
Abstract: ABSTRACT Inadequate delivery of oxygen to organisms during development can lead to cell dysfunction/death and life‐long disabilities. Although the susceptibility of developing cells to low oxygen conditions changes with maturation, the cellular and molecular pathways… read more here.
Keywords: elegans anoxia; susceptibility developing; signaling regulates; developing elegans ... See more keywords
Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stem Cell"
DOI: 10.1016/j.stem.2020.11.009
Abstract: SARS-CoV-2 infection has led to a global health crisis, and yet our understanding of the disease and potential treatment options remains limited. The infection occurs through binding of the virus with angiotensin converting enzyme 2… read more here.
Keywords: androgen signaling; covid; signaling regulates; levels associated ... See more keywords
Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2203849119
Abstract: Significance As a general model for cell cycle control, repressors keep cells quiescent until growth signals remove the inhibition. For S phase, this is exemplified by the Retinoblastoma (RB) protein and its inactivation. It was… read more here.
Keywords: signaling regulates; cell; regulates hepatocyte; cell division ... See more keywords
Wnt Signaling Regulates MFSD2A-dependent Drug Delivery through Endothelial Transcytosis in Glioma.
Sign Up to like & getrecommendations! Published in 2023 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac288
Abstract: BACKGROUND Systemic delivery of anti-tumor therapeutic agents to brain tumors is thwarted by the blood-brain barrier (BBB), an organotypic specialization of brain endothelial cells (ECs). A failure of pharmacological compounds to cross BBB is one… read more here.
Keywords: signaling regulates; transcytosis; tmz delivery; glioma ... See more keywords
Glucocorticoid signaling regulates cell invasion and migration in the human first‐trimester trophoblast cell line Sw.71
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.12974
Abstract: The development of the placenta and its functions are sensitive to infection and stress, which can activate the hypothalamic‐pituitary‐adrenal axis. Adrenally produced glucocorticoids are the body's primary mediators of the inflammatory and stress response. Although… read more here.
Keywords: regulates cell; glucocorticoid signaling; invasion migration; signaling regulates ... See more keywords
Notch signaling regulates nuclear androgen receptor AR and membrane androgen receptor ZIP9 in mouse Sertoli cells
Sign Up to like & getrecommendations! Published in 2019 at "Andrology"
DOI: 10.1111/andr.12691
Abstract: Notch signaling pathway is involved in contact‐dependent communication between the cells of seminiferous epithelium, and its proper activity is important for undisturbed spermatogenesis. read more here.
Keywords: androgen; regulates nuclear; signaling regulates; notch signaling ... See more keywords
Bradykinin signaling regulates solute permeability and cellular junction organization in lymphatic endothelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Microcirculation"
DOI: 10.1111/micc.12592
Abstract: Determine the effect of bradykinin on solute permeability and cellular junctional proteins in human dermis microvascular endothelial cells. read more here.
Keywords: permeability cellular; solute permeability; signaling regulates; endothelial cells ... See more keywords
Hepatic Gi signaling regulates whole-body glucose homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci94505
Abstract: An increase in hepatic glucose production (HGP) is a key feature of type 2 diabetes. Excessive signaling through hepatic Gs–linked glucagon receptors critically contributes to pathologically elevated HGP. Here, we tested the hypothesis that this… read more here.
Keywords: glucose homeostasis; regulates whole; hepatic signaling; hgp ... See more keywords
Sucrose Signaling Regulates Anthocyanin Biosynthesis Through a MAPK Cascade in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2018 at "Genetics"
DOI: 10.1534/genetics.118.301470
Abstract: Anthocyanin accumulation specifically depends on sucrose (Suc) signaling. However, the molecular basis of this process remains unknown. In this study, in vitro pull-down assays identified ETHYLENE-INSENSITIVE3 (EIN3), a component of both sugar signaling or/and metabolism.… read more here.
Keywords: ein3; yda ein3; anthocyanin accumulation; signaling regulates ... See more keywords