Controlling Wnt Signaling Specificity and Implications for Targeting WNTs Pharmacologically.
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DOI: 10.1007/164_2021_529
Abstract: Wnt signaling is critical for proper development of the embryo and for tissue homeostasis in the adult. Activation of this signaling cascade is initiated by binding of the secreted Wnts to their receptors. With the… read more here.
Keywords: specificity implications; wnt signaling; wnt; implications targeting ... See more keywords
Signaling specificity in the c-di-GMP-dependent network regulating antibiotic synthesis in Lysobacter
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DOI: 10.1093/nar/gky803
Abstract: Abstract Enzymes controlling intracellular second messengers in bacteria, such as c-di-GMP, often affect some but not other targets. How such specificity is achieved is understood only partially. Here, we present a novel mechanism that enables… read more here.
Keywords: gmp; gmp dependent; lysobacter; signaling specificity ... See more keywords
A threshold model for receptor tyrosine kinase signaling specificity and cell fate determination
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DOI: 10.12688/f1000research.14143.1
Abstract: Upon ligand engagement, the single-pass transmembrane receptor tyrosine kinases (RTKs) dimerize to transmit qualitatively and quantitatively different intracellular signals that alter the transcriptional landscape and thereby determine the cellular response. The molecular mechanisms underlying these… read more here.
Keywords: receptor tyrosine; model; threshold model; signaling specificity ... See more keywords