S1P Signaling in the Tumor Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-35582-1_7
Abstract: Sphingosine-1-phosphate (S1P), together with other phosphosphingolipids, has been found to regulate complex cellular function in the tumor microenvironment (TME) where it acts as a signaling molecule that participates in cell-cell communication. S1P, through intracellular and… read more here.
Keywords: signaling tumor; s1p signaling; s1p; tumor microenvironment ... See more keywords
Adenosine Signaling in the Tumor Microenvironment.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-47189-7_9
Abstract: Adenosine, deriving from ATP released by dying cancer cells and then degradated in the tumor environment by CD39/CD73 enzyme axis, is linked to the generation of an immunosuppressed niche favoring the onset of neoplasia. Signals… read more here.
Keywords: adenosine signaling; signaling tumor; adenosine; tumor microenvironment ... See more keywords
IL-22 Signaling in the Tumor Microenvironment.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-55617-4_5
Abstract: Interleukin (IL)-22 belongs to the IL-10 cytokine family which performs biological functions by binding to heterodimer receptors comprising a type 1 receptor chain (R1) and a type 2 receptor chain (R2). IL-22 is mainly derived… read more here.
Keywords: chain; signaling tumor; receptor; tumor microenvironment ... See more keywords
Proteoglycan signaling in tumor angiogenesis and endothelial cell autophagy.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2019.05.003
Abstract: The need for more effective cancer therapies is omnipresent as the ever-complex, and highly adaptive, mechanisms of tumor biology allow this disease to elude even the most stringent treatment options. The expanding field of proteoglycan… read more here.
Keywords: tumor angiogenesis; signaling tumor; biology; proteoglycan signaling ... See more keywords
Abstract 522: PI3K/Akt signaling in tumor cells promotes immune evasion by limiting infiltration, recognition and killing by T cells
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-522
Abstract: The presence of tumor-infiltrating T cells is associated with favorable patient outcomes, yet most pancreatic cancers are immunologically silent and resistant to currently available immunotherapy. In this study, a syngeneic orthotopic implantation model of pancreatic… read more here.
Keywords: tumor cells; tumor; akt signaling; pi3k akt ... See more keywords
PRAS40 signaling in tumor
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17299
Abstract: The proline-rich Akt substrate of 40 kDa (PRAS40) is a substrate of Akt and a component of the mammalian target of rapamycin complex 1 (mTORC1). Locating at the crossroad of the PI3K/Akt pathway and the… read more here.
Keywords: signaling tumor; pras40 signaling; pras40; tumor ... See more keywords