EGFR and Prion protein promote signaling via FOXO3a‐KLF5 resulting in clinical resistance to platinum agents in colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12411
Abstract: Epidermal growth factor receptor (EGFR) supports colorectal cancer progression via oncogenic signaling. Anti‐EGFR therapy is being investigated as a clinical option for colorectal cancer, and an observed interaction between EGFR and Prion protein has been… read more here.
Keywords: egfr; platinum; colorectal cancer; resistance ... See more keywords
Estrogen receptor variant ER‐α36 facilitates estrogen signaling via EGFR in glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11877
Abstract: Glioblastoma (GBM) is a deadly and common primary brain tumor. Poor prognosis is linked to high proliferation and cell heterogeneity. Sex differences may play a role in patient outcome. Previous studies showed that ER‐α36, a… read more here.
Keywords: signaling via; estrogen receptor; estrogen; gbm ... See more keywords
Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.05.017
Abstract: Maintaining energy homeostasis upon environmental challenges, such as cold or excess calorie intake, is essential to the fitness and survival of mammals. Drug discovery efforts targeting β-adrenergic signaling have not been fruitful after decades of… read more here.
Keywords: chrna2; beige fat; independent signaling; via chrna2 ... See more keywords
The Arabidopsis NLP7 gene regulates nitrate signaling via NRT1.1–dependent pathway in the presence of ammonium
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20038-4
Abstract: Nitrate is not only an important nutrient but also a signaling molecule for plants. A few of key molecular components involved in primary nitrate responses have been identified mainly by forward and reverse genetics as… read more here.
Keywords: nlp7 gene; arabidopsis nlp7; nitrate signaling; gene regulates ... See more keywords
Nitric oxide dependent signaling via cyclic GMP in dendritic cells regulates migration and T-cell polarization
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-29287-9
Abstract: Allergic airway inflammation is accompanied by excessive generation of nitric oxide (NO). Beside its detrimental activity due to the generation of reactive nitrogen species, NO was found to modulate immune responses by activating the NO-sensitive… read more here.
Keywords: camp; oxide dependent; cyclic gmp; signaling via ... See more keywords
Within-plant signaling via volatiles in beech (Fagus crenata Blume)
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Plant Interactions"
DOI: 10.1080/17429145.2020.1742393
Abstract: ABSTRACT Many plants exhibit systemic induced resistance (SIR) coordinated among numerous branches after damage to a single localized tissue. Recently, it has been revealed that damaged leaves release a variety of volatile organic compounds (VOCs)… read more here.
Keywords: via volatiles; plant; within plant; plant signaling ... See more keywords
Lysophosphatidic acid signaling via LPA6: A negative modulator of developmental oligodendrocyte maturation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15696
Abstract: The developmental process of central nervous system (CNS) myelin sheath formation is characterized by well‐coordinated cellular activities ultimately ensuring rapid and synchronized neural communication. During this process, myelinating CNS cells, namely oligodendrocytes (OLGs), undergo distinct… read more here.
Keywords: signaling via; lpa6 negative; maturation; lysophosphatidic acid ... See more keywords
Autoinducer 2 Signaling via the Phosphotransferase FruA Drives Galactose Utilization by Streptococcus pneumoniae, Resulting in Hypervirulence
Sign Up to like & getrecommendations! Published in 2017 at "mBio"
DOI: 10.1128/mbio.02269-16
Abstract: ABSTRACT Communication between bacterial cells is crucial for the coordination of diverse cellular processes that facilitate environmental adaptation and, in the case of pathogenic species, virulence. This is achieved by the secretion and detection of… read more here.
Keywords: phosphotransferase; gram positive; system; pneumoniae ... See more keywords
Targeting Wnt Signaling via Notch in Intestinal Carcinogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11040555
Abstract: Proliferation and differentiation of intestinal epithelial cells is assisted by highly specialized and well-regulated signaling cascades. The Wnt pathway, which is one of the fundamental pathways in the intestine, contributes to the organization of proliferative… read more here.
Keywords: targeting wnt; wnt signaling; via notch; signaling via ... See more keywords
Modulation of Metabolic Hormone Signaling via a Circadian Hormone and Biogenic Amine in Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084266
Abstract: In insects, adipokinetic hormone is the primary hormone responsible for the mobilization of stored energy. While a growing body of evidence has solidified the role of adipokinetic hormone (AKH) in modulating the physiological and behavioral… read more here.
Keywords: signaling via; hormone signaling; hormone; expression ... See more keywords