Sign epistasis caused by hierarchy within signalling cascades
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03644-8
Abstract: Sign epistasis is a central evolutionary constraint, but its causal factors remain difficult to predict. Here we use the notion of parameterised optima to explain epistasis within a signalling cascade, and test these predictions in… read more here.
Keywords: sign epistasis; within signalling; hierarchy; epistasis ... See more keywords
P140 Identification of affimers that bind to the IL-7R and inhibits the IL-7 signalling cascade
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-ewrr2019.124
Abstract: Career situation of first and presenting author Student for a master or a PhD. Introduction IL-7R is a heterodimer constituted by the IL-7R alpha (α) chain (CD127) and the common gamma (g) chain (CD132). IL-7… read more here.
Keywords: cascade; inhibits signalling; hek il7r; signalling cascade ... See more keywords
A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach
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DOI: 10.1136/gutjnl-2016-312779
Abstract: Objective Alternatively activated macrophages (M2) are associated with the progression of spasmolytic polypeptide-expressing metaplasia (SPEM) in the stomach. However, the precise mechanism(s) and critical mediators that induce SPEM are unknown. Design To determine candidate genes… read more here.
Keywords: parietal cell; cell loss; stomach; mice ... See more keywords