Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23653-4
Abstract: Generating properly differentiated embryonic structures in vitro from pluripotent stem cells remains a challenge. Here we show that instruction of aggregates of mouse embryonic stem cells with an experimentally engineered morphogen signalling centre, that functions… read more here.
Keywords: signalling centre; mammalian embryo; morphogen signalling; stem ... See more keywords
Distinct pathways drive anterior hypoblast specification in the implanting human embryo
Sign Up to like & getrecommendations! Published in 2024 at "Nature Cell Biology"
DOI: 10.1038/s41556-024-01367-1
Abstract: Development requires coordinated interactions between the epiblast, which generates the embryo proper; the trophectoderm, which generates the placenta; and the hypoblast, which forms both the anterior signalling centre and the yolk sac. These interactions remain… read more here.
Keywords: hypoblast; hypoblast specification; specification; anterior hypoblast ... See more keywords